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CPT 81529 Fee Schedule

Last Verified: October 2025

Healthcare providers use this code to document and receive reimbursement for visits that address high-level medical decision-making, often including multiple diagnoses or prescription management.

"Oncology (Cutaneous Melanoma), Mrna, Gene Expression Profiling By Real-Time Rt-Pcr Of 31 Genes (28 Content And 3 Housekeeping), Utilizing Formalin-Fixed Paraffin-Embedded Tissue, Algorithm Reported As Recurrence Risk, Including Likelihood Of Sentinel Lymph Node Metastasis"
Key FactDetail
Service Type

Pathology and Laboratory Procedures

Multianalyte Assays with Algorithmic Analyses

Common Place of Service

81 - Independent Laboratory

Common Modifiers

None

59 - Distinct Procedural Service

Complexity LevelHigh

National average reimbursement for CPT 81529 by major payers:

bcbs

$5,827.53

uhc

$4,404.63

aetna

$6,508.51

cigna

$10,252.77

Preview provider-level rates for...
For billing codeCPT 81529
PayerCodeRateNPITax IDStateSpecialty

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CPT 81529 vs. Other Multianalyte Assays with Algorithmic Analyses Codes

The CPT 81529 code is part of the Pathology and Laboratory Procedures services used for Multianalyte Assays with Algorithmic Analyses. It represents a moderate-complexity encounter and is one of several codes that vary based on time spent, level of medical decision-making, and documentation requirements.

The CPT 81529 code involves more provider time and moderate medical decision-making, unlike lower-level codes that require less time and simpler assessments. It typically includes multiple diagnoses, medication management, or test interpretation, leading to higher reimbursement and more detailed documentation requirements.

CodeComplexityDescription
81525HighOncology (Colon), Mrna, Gene Expression Profiling By Real-Time Rt-Pcr Of 12 Genes (7 Content And 5 Housekeeping), Utilizing Formalin-Fixed Paraffin-Embedded Tissue, Algorithm Reported As A Recurrence Score
81528ModerateOncology (Colorectal) Screening Quantitative Real-Time Target And Signal Amplification Of 10 Dna Markers (Kras Mutations Promoter Methylation Of Ndrg4 And Bmp3) And Fecal Hemoglobin Utilizing Stool Algorithm Reported As A Positive Or Negative Result
81529High"Oncology (Cutaneous Melanoma), Mrna, Gene Expression Profiling By Real-Time Rt-Pcr Of 31 Genes (28 Content And 3 Housekeeping), Utilizing Formalin-Fixed Paraffin-Embedded Tissue, Algorithm Reported As Recurrence Risk, Including Likelihood Of Sentinel Lymph Node Metastasis"
81535ModerateOncology (Gynecologic) Liver Tumor Cell Culture And Chemotherapeutic Response By Dapi Stain And Morphology Predictive Algorithm Reported As A Drug Response Score; First Single Drug Or Drug Combination.

What is a fee schedule?

A fee schedule is a list of fixed prices that healthcare providers charge for specific services, including CPT 81529. These prices vary depending on payer type (Medicare, Medicaid, private insurance), geographic location, and provider contracts.

Understanding the 81529 fee schedule helps patients estimate costs and providers optimize billing for accurate reimbursements.

Factors that affect fee schedules


Medicare & Medicaid Rates

Government-set reimbursement amounts


Private Insurance Rates

Negotiated rates between providers and insurance companies


Geographic Location

Costs may be higher in urban areas.


Provider Type

Hospital providers may have different rates than private practice.

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Medicare Reimbursement Lookup Tool

Medicare localities are geographic regions used to adjust reimbursement rates based on local costs. Rates vary by locality to reflect differences in wages, rent, and other expenses. Sign up to see commercial rates (United/BCBS/Cigna/Aetna)

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YearBilling CodeLocalityNon-Facility FeeFacility Fee