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See a sample rate comparisonHealthcare providers use this code to document and receive reimbursement for visits that address high-level medical decision-making, often including multiple diagnoses or prescription management.
| Key Fact | Detail |
|---|---|
| Service Type | Pathology and Laboratory Procedures Multianalyte Assays with Algorithmic Analyses |
| Common Place of Service | 81 - Independent Laboratory |
| Common Modifiers | 59 - Distinct Procedural Service |
| Complexity Level | High |
| Medicare Fee Schedule | $7,193.00 national lab fee schedule rate (2026) · View Medicare rates for 81529 |
| Medicaid Fee Schedule | $7,121.065 median of the 8 states in the free preview · View Medicaid rates for 81529 |
National average reimbursement for CPT 81529 by major payers:

$5,827.53

$4,404.63

$6,508.51

$10,252.77
Choose a payer to see a sample of rates for CPT 81529.
Chu Chen
Merrimack Valley Pediatric Associates, Inc.
Christopher Raio
Mercy Medical Center
Baycare Home Care, Inc.
Baycare Home Care Inc
Christopher Raio
St Francis Hospital
Sunrise Home Health Care Inc.
Sunrise Home Health Care Inc
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Rate Benchmarking
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See a sample payer proposalCPT 81529 vs. Other Multianalyte Assays with Algorithmic Analyses Codes
The CPT 81529 code is part of the Pathology and Laboratory Procedures services used for Multianalyte Assays with Algorithmic Analyses. It represents a moderate-complexity encounter and is one of several codes that vary based on time spent, level of medical decision-making, and documentation requirements.
The CPT 81529 code involves more provider time and moderate medical decision-making, unlike lower-level codes that require less time and simpler assessments. It typically includes multiple diagnoses, medication management, or test interpretation, leading to higher reimbursement and more detailed documentation requirements.
| Code | Complexity | Description |
|---|---|---|
| 81525-CPT | High | Pathology Panel/Obstetric, Oncology (Colon) Mrna Gene Expression Profiling By Real-Time Rt-Pcr Of 12 Genes (7 Content And 5 Housekeeping) Utilizing Formalin-Fixed Paraffin-Embedded Tissue Algorithm Reported As A Recurrence Score |
| 81528-CPT | Moderate | Cologuard-Oncology (Colorectal, Cologuard-Oncology (Colorectal) Screening Quantitative Real-Time Target And Signal Amplification Of10 Dna Markers (Kras Mutations Promoter Methylat Ion Of Ndrg4 And Bmp3) And Fecal Hemoglobin Utilizing Stool Algorithm Reported As A Positive Or Negative Result |
| 81529-CPT | High | Onc Cutan Mlnma Mrna 31 Gene, Oncology Cutaneous Melanoma Mrna Gene Expression Profiling By Real Time Rt Pcr Of 31 Genes 28 Content And 3 Housekeeping Utilizing Formalin Fixed Paraffin Embedded Tissue Algorithm Reported As Recurrence Risk Including Likelihood Of Sentinel Lymph Node Metastasis |
| 81535-CPT | Moderate | Oncology (Gynecologic) Live T, Oncology (Gynecologic) Live Tumor Cell Culture And Chemotherapeutic Response By Dapi Stain And Morphology Predictive Algorithm Reported As A Drug Response Score First Single Drug Or Drug Combinatio |
What is a fee schedule?
A fee schedule is a list of fixed prices that healthcare providers charge for specific services, including CPT 81529. These prices vary depending on payer type (Medicare, Medicaid, private insurance), geographic location, and provider contracts.
Understanding the 81529 fee schedule helps patients estimate costs and providers optimize billing for accurate reimbursements.
Factors that affect fee schedules
Medicare & Medicaid Rates
Government-set reimbursement amounts
Private Insurance Rates
Negotiated rates between providers and insurance companies
Geographic Location
Costs may be higher in urban areas.
Provider Type
Hospital providers may have different rates than private practice.
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