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CPT 81596 Fee Schedule

Last Verified: October 2025

Healthcare providers use this code to document and receive reimbursement for visits that address moderate-level medical decision-making, often including multiple diagnoses or prescription management.

Infectious Disease Chronic Hepatitis C Virus (Hcv) Infection Six Biochemical Assays (Alt A2-Macroglobulin Apolipoprotein A-1 Total Bilirubin Ggt And Haptoglobin) Utilizing Serum Prognostic Algorithm Reported As Scores For Fibrosis And Necroinflammatory Activity In Liver
Key FactDetail
Service Type

Pathology and Laboratory Procedures

Multianalyte Assays with Algorithmic Analyses

Common Place of Service

81 - Independent Laboratory

11 - Office

Common Modifiers

None

90 - Reference Laboratory

TC - Technical component

Complexity LevelModerate

National average reimbursement for CPT 81596 by major payers:

bcbs

$57.44

uhc

$44.26

aetna

$70.65

cigna

$128.81

Preview provider-level rates for...
For billing codeCPT 81596
PayerCodeRateNPITax IDStateSpecialty

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CPT 81596 vs. Other Multianalyte Assays with Algorithmic Analyses Codes

The CPT 81596 code is part of the Pathology and Laboratory Procedures services used for Multianalyte Assays with Algorithmic Analyses. It represents a moderate-complexity encounter and is one of several codes that vary based on time spent, level of medical decision-making, and documentation requirements.

The CPT 81596 code involves more provider time and moderate medical decision-making, unlike lower-level codes that require less time and simpler assessments. It typically includes multiple diagnoses, medication management, or test interpretation, leading to higher reimbursement and more detailed documentation requirements.

CodeComplexityDescription
81560ModerateCtransplantation Medicine (Allograft Rejection, Pediatric Liver And Small Bowel), Measurement Of Donor And Third-Party-Induced Cd154+Tu0002cytotoxic Memory Cells, Utilizing Whole Peripheral Blood, Algorithm Reported As A Rejection Risk Score
81595HighCardiology (Heart Transplant) Mrna Gene Expression Profiling By Real-Time Quantitative Pcrof 20 Genes (11 Content And 9 Housekeeping) Utilizing Subfraction Of Peripheral Blood Algorithm Reported As A Rejection Risk Score.
81596LowInfectious Disease Chronic Hepatitis C Virus (Hcv) Infection Six Biochemical Assays (Alt A2-Macroglobulin Apolipoprotein A-1 Total Bilirubin Ggt And Haptoglobin) Utilizing Serum Prognostic Algorithm Reported As Scores For Fibrosis And Necroinflammatory Activity In Liver
81599ModerateUnlisted Multianalyte Assay With Algorithmic Analysis

What is a fee schedule?

A fee schedule is a list of fixed prices that healthcare providers charge for specific services, including CPT 81596. These prices vary depending on payer type (Medicare, Medicaid, private insurance), geographic location, and provider contracts.

Understanding the 81596 fee schedule helps patients estimate costs and providers optimize billing for accurate reimbursements.

Factors that affect fee schedules


Medicare & Medicaid Rates

Government-set reimbursement amounts


Private Insurance Rates

Negotiated rates between providers and insurance companies


Geographic Location

Costs may be higher in urban areas.


Provider Type

Hospital providers may have different rates than private practice.

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Medicare Reimbursement Lookup Tool

Medicare localities are geographic regions used to adjust reimbursement rates based on local costs. Rates vary by locality to reflect differences in wages, rent, and other expenses. Sign up to see commercial rates (United/BCBS/Cigna/Aetna)

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YearBilling CodeLocalityNon-Facility FeeFacility Fee