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HCPCS J2781 (Syfovre) Fee Schedule

Last Verified: July 2026

Healthcare providers use this code to document and receive reimbursement for visits that address moderate-level medical decision-making, often including multiple diagnoses or prescription management.

Injection, pegcetacoplan, intravitreal, 1 mg
Key FactDetail
Service Type

Drugs Administered Other than Oral Method

Drugs, Administered by Injection

Complexity LevelLow
Medicare Payment Limit
$139.181BuyandBill.com
WAC Price
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National average reimbursement for HCPCS J2781 by major payers:

bcbs

$143.50

uhc

$149.69

aetna

$266.71

cigna

$160.11

Preview provider-level rates for...
For billing codeHCPCS J2781
PayerCodeRateNPITax IDStateSpecialty
United
J2781$147.361851336044 - ST. JOSEPHS COMMUNITY HOSPITAL OF WEST BEND INC., FROEDTERT WEST BEND HOSPITAL390806302 - (WI) ST JOSEPHS COMMUNITY HOSPITAL OF WEST BEND INCWIGeneral Acute Care Hospital (282N00000X)
United
J2781$147.361184826083 - LARISA TRAILL381437919 - MYMICHIGAN MEDICAL CENTER ALMAMIGeneral Acute Care Hospital (282N00000X)
United
J2781$134.161659330173 - MERCY MEDICAL CENTER111635088 - (NY) MERCY MEDICAL CENTERNYGeneral Acute Care Hospital (282N00000X)
United
J2781$147.361225087786 - MARION VAMC351516418 - MARION VAMCINGeneral Acute Care Hospital (282N00000X)
United
J2781$147.361356320873 - EAST TEXAS MEDICAL CENTER ATHENS751854562 - (TX) ETX SUCCESSOR ATHENSTXGeneral Acute Care Hospital (282N00000X)
United
J2781$395.041528006103 - BRYAN MEDICAL CENTER470376552 - BRYAN MEDICAL CENTERNEGeneral Acute Care Hospital (282N00000X)
United
J2781$146.361245318609 - ST CATHERINE OF SIENA MEDICAL CENTER61562701 - (NY) ST CATHERINE OF SIENA MEDICAL CENTERNYGeneral Acute Care Hospital (282N00000X)
United
J2781$203.191134550239 - MARKUS PLATE131623978NYGeneral Acute Care Hospital (282N00000X)
United
J2781$149.071104857119 - PUBLIC HEALTH TRUST OF MIAMI DADE COUNTY FLORIDA, JACKSON NORTH MEDICAL CENTER591713947 - (FL) PUBLIC HEALTH TRUST OF MIAMI-DADE COUNTY FLORIDAFLGeneral Acute Care Hospital (282N00000X)
United
J2781$149.071639422504 - EMERUS BHS SA THOUSAND OAKS, LLC, BAPTIST NEIGHBORHOOD HOSPITAL SCHERTZ452497248 - (TX) EMERUS BHS SA THOUSAND OAKS LLCTXGeneral Acute Care Hospital (282N00000X)
United
J2781$228.971255891958 - PIEDMONT NEWTON EKG BILLING LLC814475074 - (GA) PIEDMONT NEWTON HOSPITAL INCGAGeneral Acute Care Hospital (282N00000X)
United
J2781$181.861447221056 - THE HEALTH CARE AUTHORITY OF THE CITY OF HUNTSVILLE, HUNTSVILLE HOSPITAL630845288ALGeneral Acute Care Hospital (282N00000X)
United
J2781$147.361053541177 - NADIV SHAPIRA, M.D. LLC270560572DEGeneral Acute Care Hospital (282N00000X)
United
J2781$220.221578504056 - MERCY HOSPITAL SPRINGFIELD, MERCY HOSPITAL SPRINGFIELD440552485 - MERCY HOSPITAL SPRINGFIELDMOGeneral Acute Care Hospital (282N00000X)
United
J2781$147.361184639973 - THE GRIFFIN HOSPITAL60647014 - (CT) GRIFFIN HOSPITALCTGeneral Acute Care Hospital (282N00000X)
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist

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HCPCS J2781 vs. Other Drugs, Administered by Injection Codes

The HCPCS J2781 code is part of the Drugs Administered Other than Oral Method services used for Drugs, Administered by Injection. It represents a moderate-complexity encounter and is one of several codes that vary based on time spent, level of medical decision-making, and documentation requirements.

The HCPCS J2781 code involves more provider time and moderate medical decision-making, unlike lower-level codes that require less time and simpler assessments. It typically includes multiple diagnoses, medication management, or test interpretation, leading to higher reimbursement and more detailed documentation requirements.

CodeComplexityDescription
J2781-HCPCSLowInjection, pegcetacoplan, intravitreal, 1 mg

What is a fee schedule?

A fee schedule is a list of fixed prices that healthcare providers charge for specific services, including HCPCS J2781. These prices vary depending on payer type (Medicare, Medicaid, private insurance), geographic location, and provider contracts.

Understanding the J2781 fee schedule helps patients estimate costs and providers optimize billing for accurate reimbursements.

Factors that affect fee schedules


Medicare & Medicaid Rates

Government-set reimbursement amounts


Private Insurance Rates

Negotiated rates between providers and insurance companies


Geographic Location

Costs may be higher in urban areas.


Provider Type

Hospital providers may have different rates than private practice.

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