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CPT 80321 Fee Schedule

Last Verified: January 2026

Healthcare providers use this code to document and receive reimbursement for visits that address moderate-level medical decision-making, often including multiple diagnoses or prescription management.

Definitive Drug Testing; Alcohol Biomarkers; 1 Or 2
Key FactDetail
Service Type

Pathology and Laboratory Procedures

Therapeutic Drug Assays

Common Place of Service

81 - Independent Laboratory

22 - On Campus Outpatient Hospital

Common Modifiers

None

26 - Professional component

90 - Reference Laboratory

Complexity LevelLow
Medicare Fee ScheduleView Medicare rates for 80321

National average reimbursement for CPT 80321 by major payers:

bcbs

$26.44

uhc

$20.61

aetna

$2.13

cigna

$45.66

Preview provider-level rates for...
For billing codeCPT 80321
PayerCodeRateNPITax IDStateSpecialty

Select a payer to view fee schedule data

Choose a payer from the options above to see rates for CPT 80321

United
80321$6.171689655912 - NOCONA HOSPITAL DISTRICT, NOCONA GENERAL HOSPITAL751368648TXGeneral Acute Care Hospital (282N00000X)
United
80321$13.221780638833 - CARTERSVILLE MEDICAL CENTER LLC, CARTERSVILLE MEDICAL CENTER582433438 - (GA) CARTERSVILLE MEDICAL CENTER LLCGAGeneral Acute Care Hospital (282N00000X)
United
80321$13.221982600540 - UNIVERSITY MCDUFFIE COUNTY REGIONAL MEDICAL CENTER, INC., PIEDMONT MCDUFFIE HOSPITAL454166209 - (GA) UNIVERSITY MCDUFFIE COUNTY REGIONAL MEDICAL CENTER INCGAGeneral Acute Care Hospital (282N00000X)
United
80321$6.171689655912 - NOCONA HOSPITAL DISTRICT, NOCONA GENERAL HOSPITAL751368648TXGeneral Acute Care Hospital (282N00000X)
United
80321$13.221407947336 - CLHG-VILLE PLATTE LLC, MERCY REGIONAL MEDICAL CENTER824681222LAGeneral Acute Care Hospital (282N00000X)
United
80321$13.221255401519 - THE MEDICAL CENTER INC, PIEDMONT COLUMBUS REGIONAL MIDTOWN581685139 - (GA) THE MEDICAL CENTER INCGAGeneral Acute Care Hospital (282N00000X)
United
80321$6.171689655912 - NOCONA HOSPITAL DISTRICT, NOCONA GENERAL HOSPITAL751368648TXGeneral Acute Care Hospital (282N00000X)
United
80321$6.171851390967 - UHS OF TEXOMA, INC, TEXOMA MEDICAL CENTER205908627 - UHS OF TEXOMA INCTXGeneral Acute Care Hospital (282N00000X)
United
80321$8.811235685892 - FAIRFIELD HOSPITAL DISTRICT, FREESTONE MEDICAL CENTER741774669TXGeneral Acute Care Hospital (282N00000X)
United
80321$13.471073502985 - CHU CHEN42484572 - MERRIMACK VALLEY PEDIATRIC ASSOCIATES, INC.MAPediatrics Physician (208000000X)
United
80321$17.631972517365 - COVENANT MEDICAL CENTER822913146 - (TX) COVENANT MEDICAL CENTERTXGeneral Acute Care Hospital (282N00000X)
United
80321$8.811881665164 - CLHG-LEESVILLE, BYRD REGIONAL HOSPITAL824337635LAGeneral Acute Care Hospital (282N00000X)
United
80321$13.221104819366 - CHILDREN'S HOSPITAL720467503 - CHILDRENS HOSPITAL INCLAChildren's Hospital (282NC2000X)
United
80321$13.221407947336 - CLHG-VILLE PLATTE LLC, MERCY REGIONAL MEDICAL CENTER824681222LAGeneral Acute Care Hospital (282N00000X)
United
80321$8.811467442418 - NORTHWEST TEXAS HEALTHCARE SYSTEM INC, NORTHWEST TEXAS HEALTHCARE SYSTEM232238976TXGeneral Acute Care Hospital (282N00000X)
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist

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CPT 80321 vs. Other Therapeutic Drug Assays Codes

The CPT 80321 code is part of the Pathology and Laboratory Procedures services used for Therapeutic Drug Assays. It represents a moderate-complexity encounter and is one of several codes that vary based on time spent, level of medical decision-making, and documentation requirements.

The CPT 80321 code involves more provider time and moderate medical decision-making, unlike lower-level codes that require less time and simpler assessments. It typically includes multiple diagnoses, medication management, or test interpretation, leading to higher reimbursement and more detailed documentation requirements.

CodeComplexityDescription
80306-CPTLowDrug Test(S) Presumptive Any Number Of Drug Classes Any Number Of Devices Or Procedures; Read By Instrument Assisted Direct Optical Observation (Eg Utilizing Immunoassay [Eg Dipsticks Cups Cards Or Cartridges]) Includes Sample Validation When Performed Per Date Of Service (Desc Revised 1/1/2018)
80307-CPTLowDrug Test(S) Presumptive Any Number Of Drug Classes Any Number Of Devices Or Procedures; By Instrument Chemistry Analyzers (Eg Utilizing Immunoassay [Eg Eia Elisa Emit Fpia Ia Kims Ria]) Chromatography (Eg Gc Hplc) And Mass Spectrometry Either With Or Without Chromatography(Eg Dart Desi Gc-Ms Gc-Ms/Ms Lc-Ms Lc-Ms/Ms Ldtd Maldi Tof) Includes Sample Validation When Performed Per Date Of Service (Desc Revised 1/1/2018)
80320-CPTLowLab Tests Other Nonmedicare Fee Schedule
80321-CPTLowDefinitive Drug Testing; Alcohol Biomarkers; 1 Or 2

What is a fee schedule?

A fee schedule is a list of fixed prices that healthcare providers charge for specific services, including CPT 80321. These prices vary depending on payer type (Medicare, Medicaid, private insurance), geographic location, and provider contracts.

Understanding the 80321 fee schedule helps patients estimate costs and providers optimize billing for accurate reimbursements.

Factors that affect fee schedules


Medicare & Medicaid Rates

Government-set reimbursement amounts


Private Insurance Rates

Negotiated rates between providers and insurance companies


Geographic Location

Costs may be higher in urban areas.


Provider Type

Hospital providers may have different rates than private practice.

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