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CPT 80321 Fee Schedule

Last Verified: November 2025

Healthcare providers use this code to document and receive reimbursement for visits that address moderate-level medical decision-making, often including multiple diagnoses or prescription management.

Definitive Drug Testing; Alcohol Biomarkers; 1 Or 2
Key FactDetail
Service Type

Pathology and Laboratory Procedures

Therapeutic Drug Assays

Common Place of Service

81 - Independent Laboratory

22 - On Campus Outpatient Hospital

Common Modifiers

None

26 - Professional component

90 - Reference Laboratory

Complexity LevelLow

National average reimbursement for CPT 80321 by major payers:

bcbs

$26.44

uhc

$20.61

aetna

$2.13

cigna

$45.66

Preview provider-level rates for...
For billing codeCPT 80321
PayerCodeRateNPITax IDStateSpecialty

Select a payer to view fee schedule data

Choose a payer from the options above to see rates for CPT 80321

United
80321$8.811306843826 - WEST CARROLL HEALTH SYSTEMS LLC, WEST CARROLL MEMORIAL HOSPITAL562300247 - WEST CARROLL HEALTH SYSTEMS L.L.C.LAGeneral Acute Care Hospital (282N00000X)
United
80321$8.811467442418 - NORTHWEST TEXAS HEALTHCARE SYSTEM INC, NORTHWEST TEXAS HEALTHCARE SYSTEM232238976TXGeneral Acute Care Hospital (282N00000X)
United
80321$13.221265437644 - WEST JEFFERSON HOLDINGS, LLC, WEST JEFFERSON MEDICAL CENTER472667968 - WEST JEFFERSON HOLDINGS, LLCLAGeneral Acute Care Hospital (282N00000X)
United
80321$13.221720589328 - PIEDMONT WALTON HOSPITAL INC824194264 - (GA) PIEDMONT WALTON HOSPITAL INCGAGeneral Acute Care Hospital (282N00000X)
United
80321$13.471073502985 - CHU CHEN42484572 - MERRIMACK VALLEY PEDIATRIC ASSOCIATES, INC.MAPediatrics Physician (208000000X)
United
80321$13.221225034333 - PIEDMONT HENRY HOSPITAL, INC.582200195 - (GA) PIEDMONT HENRY HOSPITAL INCGAGeneral Acute Care Hospital (282N00000X)
United
80321$13.221134133002 - PIEDMONT NEWNAN HOSPITAL, INC.205077249 - (GA) PIEDMONT NEWNAN HOSPITAL INCGAGeneral Acute Care Hospital (282N00000X)
United
80321$13.221982600540 - UNIVERSITY MCDUFFIE COUNTY REGIONAL MEDICAL CENTER, INC., PIEDMONT MCDUFFIE HOSPITAL454166209 - (GA) UNIVERSITY MCDUFFIE COUNTY REGIONAL MEDICAL CENTER INCGAGeneral Acute Care Hospital (282N00000X)
United
80321$13.471073502985 - CHU CHEN42484572 - MERRIMACK VALLEY PEDIATRIC ASSOCIATES, INC.MAPediatrics Physician (208000000X)
United
80321$13.471073502985 - CHU CHEN42484572 - MERRIMACK VALLEY PEDIATRIC ASSOCIATES, INC.MAPediatrics Physician (208000000X)
United
80321$13.471073502985 - CHU CHEN42484572 - MERRIMACK VALLEY PEDIATRIC ASSOCIATES, INC.MAPediatrics Physician (208000000X)
United
80321$13.221437186111 - PIEDMONT ATHENS REGIONAL MEDICAL CENTER, INC.582179986 - (GA) PIEDMONT ATHENS REGIONAL MEDICAL CENTER INCGAGeneral Acute Care Hospital (282N00000X)
United
80321$13.221760498588 - PIEDMONT NEWTON HOSPITAL, INC., NEWTON MEDICAL CENTER582155150 - (GA) PIEDMONT NEWTON HOSPITAL INCGAGeneral Acute Care Hospital (282N00000X)
United
80321$6.171851390967 - UHS OF TEXOMA, INC, TEXOMA MEDICAL CENTER205908627 - UHS OF TEXOMA INCTXGeneral Acute Care Hospital (282N00000X)
United
80321$13.221528027240 - FAYETTE COMMUNITY HOSPITAL, INC., PIEDMONT FAYETTE HOSPITAL582322328 - (GA) FAYETTE COMMUNITY HOSPITAL INCGAGeneral Acute Care Hospital (282N00000X)
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist

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CPT 80321 vs. Other Therapeutic Drug Assays Codes

The CPT 80321 code is part of the Pathology and Laboratory Procedures services used for Therapeutic Drug Assays. It represents a moderate-complexity encounter and is one of several codes that vary based on time spent, level of medical decision-making, and documentation requirements.

The CPT 80321 code involves more provider time and moderate medical decision-making, unlike lower-level codes that require less time and simpler assessments. It typically includes multiple diagnoses, medication management, or test interpretation, leading to higher reimbursement and more detailed documentation requirements.

CodeComplexityDescription
80306-CPTLowDrug Test(S) Presumptive Any Number Of Drug Classes Any Number Of Devices Or Procedures; Read By Instrument Assisted Direct Optical Observation (Eg Utilizing Immunoassay [Eg Dipsticks Cups Cards Or Cartridges]) Includes Sample Validation When Performed Per Date Of Service (Desc Revised 1/1/2018)
80307-CPTLowDrug Test(S) Presumptive Any Number Of Drug Classes Any Number Of Devices Or Procedures; By Instrument Chemistry Analyzers (Eg Utilizing Immunoassay [Eg Eia Elisa Emit Fpia Ia Kims Ria]) Chromatography (Eg Gc Hplc) And Mass Spectrometry Either With Or Without Chromatography(Eg Dart Desi Gc-Ms Gc-Ms/Ms Lc-Ms Lc-Ms/Ms Ldtd Maldi Tof) Includes Sample Validation When Performed Per Date Of Service (Desc Revised 1/1/2018)
80320-CPTLowLab Tests Other Nonmedicare Fee Schedule
80321-CPTLowDefinitive Drug Testing; Alcohol Biomarkers; 1 Or 2

What is a fee schedule?

A fee schedule is a list of fixed prices that healthcare providers charge for specific services, including CPT 80321. These prices vary depending on payer type (Medicare, Medicaid, private insurance), geographic location, and provider contracts.

Understanding the 80321 fee schedule helps patients estimate costs and providers optimize billing for accurate reimbursements.

Factors that affect fee schedules


Medicare & Medicaid Rates

Government-set reimbursement amounts


Private Insurance Rates

Negotiated rates between providers and insurance companies


Geographic Location

Costs may be higher in urban areas.


Provider Type

Hospital providers may have different rates than private practice.

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