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CPT 81216 Fee Schedule

Last Verified: July 2026

Healthcare providers use this code to document and receive reimbursement for visits that address moderate-level medical decision-making, often including multiple diagnoses or prescription management.

Brca2 Genetic Test, A Lab Analysis Of Genetic Material That Can Indicate Breast Cancer. Types Of Analysis Include Gene Variants Full Sequence Analysis Or Breakpoints.
Key FactDetail
Service Type

Genetic Analysis Procedures

Tier 1 Molecular Pathology Procedures

Common Place of Service

81 - Independent Laboratory

11 - Office

Common Modifiers

None

90 - Reference Laboratory

59 - Distinct Procedural Service

GW - Condition not related to the patient's terminal condition

Complexity LevelModerate
Medicare Fee ScheduleView Medicare rates for 81216

National average reimbursement for CPT 81216 by major payers:

bcbs

$208.35

uhc

$113.60

aetna

$265.52

cigna

$292.39

Preview provider-level rates for...
For billing codeCPT 81216
PayerCodeRateNPITax IDStateSpecialty
United
81216$77.751366428401 - AARON ASKEW931261079 - THE ORTHOPEDIC AND NEUROSURGICAL CENTER OF THE CASCADESOROrthopaedic Trauma Physician (207XX0801X)
United
81216$99.961255478004 - CHRISTOPHER RAIO111635088 - MERCY MEDICAL CENTERNYEmergency Medicine Physician (207P00000X)
United
81216$219.921255478004 - CHRISTOPHER RAIO111635088 - MERCY MEDICAL CENTERNYEmergency Medicine Physician (207P00000X)
United
81216$184.931255478004 - CHRISTOPHER RAIO113438973 - ST JOSEPH HOSPITALNYEmergency Medicine Physician (207P00000X)
United
81216$99.961255478004 - CHRISTOPHER RAIO112050523 - ST FRANCIS HOSPITALNYEmergency Medicine Physician (207P00000X)
United
81216$203.631366428401 - AARON ASKEW931224010 - PRAXIS HEALTH, P.C.OROrthopaedic Trauma Physician (207XX0801X)
United
81216$185.121073502985 - CHU CHEN42484572 - MERRIMACK VALLEY PEDIATRIC ASSOCIATES, INC.MAPediatrics Physician (208000000X)
United
81216$244.361255478004 - CHRISTOPHER RAIO112050523 - ST FRANCIS HOSPITALNYEmergency Medicine Physician (207P00000X)
United
81216$219.921255478004 - CHRISTOPHER RAIO111635088 - MERCY MEDICAL CENTERNYEmergency Medicine Physician (207P00000X)
United
81216$219.921255478004 - CHRISTOPHER RAIO208243412 - SAMARITAN EMERGENCY MEDICAL SERVICES PCNYEmergency Medicine Physician (207P00000X)
United
81216$111.071255478004 - CHRISTOPHER RAIO113438973 - ST JOSEPH HOSPITALNYEmergency Medicine Physician (207P00000X)
United
81216$219.921255478004 - CHRISTOPHER RAIO208243412 - SAMARITAN EMERGENCY MEDICAL SERVICES PCNYEmergency Medicine Physician (207P00000X)
United
81216$247.471063491629 - JOSELYN GONZALEZ521958352 - ATLANTIC HEALTH SYSTEM INCNJInternal Medicine Physician (207R00000X)
United
81216$136.501013915149 - BAYCARE HOME CARE, INC., DBA SARASOTA MEMORIAL HOME CARE593582520 - (FL) BAYCARE HOME CARE INCFLHome Health Agency (251E00000X)
United
81216$77.751366428401 - AARON ASKEW931261079 - THE ORTHOPEDIC AND NEUROSURGICAL CENTER OF THE CASCADESOROrthopaedic Trauma Physician (207XX0801X)
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist

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CPT 81216 vs. Other Tier 1 Molecular Pathology Procedures Codes

The CPT 81216 code is part of the Genetic Analysis Procedures services used for Tier 1 Molecular Pathology Procedures. It represents a moderate-complexity encounter and is one of several codes that vary based on time spent, level of medical decision-making, and documentation requirements.

The CPT 81216 code involves more provider time and moderate medical decision-making, unlike lower-level codes that require less time and simpler assessments. It typically includes multiple diagnoses, medication management, or test interpretation, leading to higher reimbursement and more detailed documentation requirements.

CodeComplexityDescription
81210-CPTLowBraf (B-Raf Proto-Oncogene Se, Braf (B-Raf Proto-Oncogene Serinethreonine Kinase) (Eg Colon Cancer Melanoma) Gene Analysis V600 Variant(S)
81212-CPTModerateBrca1 2 185 5385 6174 Vrnt, Brca1 Brca1 Dna Repair Associated Brca2 Brca2 Dna Repair Associated Eg Hereditary Breast And Ovarian Cancer Gene Analysis 185delag 5385insc 6174delt Variants
81215-CPTModerateBrca1 Genetic Test, A Lab Analysis Of Genetic Material That Can Indicate Breast Cancer. Types Of Analysis Include Gene Variants Full Sequence Analysis Or Breakpoints.
81216-CPTModerateBrca2 Genetic Test, A Lab Analysis Of Genetic Material That Can Indicate Breast Cancer. Types Of Analysis Include Gene Variants Full Sequence Analysis Or Breakpoints.

What is a fee schedule?

A fee schedule is a list of fixed prices that healthcare providers charge for specific services, including CPT 81216. These prices vary depending on payer type (Medicare, Medicaid, private insurance), geographic location, and provider contracts.

Understanding the 81216 fee schedule helps patients estimate costs and providers optimize billing for accurate reimbursements.

Factors that affect fee schedules


Medicare & Medicaid Rates

Government-set reimbursement amounts


Private Insurance Rates

Negotiated rates between providers and insurance companies


Geographic Location

Costs may be higher in urban areas.


Provider Type

Hospital providers may have different rates than private practice.

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