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See a sample rate comparisonCPT 81222 Fee Schedule
Last Verified: September 2026
Healthcare providers use this code to document and receive reimbursement for visits that address moderate-level medical decision-making, often including multiple diagnoses or prescription management.
Cystic Fibrosis Genetic Test, A Lab Analysis Of Genetic Material That Can Indicate Cystic Fibrosis. Types Of Analysis Include Gene Variants Full Sequence Analysis Or Breakpoints.
| Key Fact | Detail |
|---|---|
| Service Type | Pathology and Laboratory Procedures Molecular Pathology Procedures |
| Common Place of Service | 81 - Independent Laboratory 11 - Office |
| Common Modifiers | None 59 - Distinct Procedural Service 90 - Reference Laboratory |
| Complexity Level | Moderate |
| Medicare Fee Schedule | View Medicare rates for 81222 |
| Medicaid Fee Schedule | View Medicaid rates for 81222 |
National average reimbursement for CPT 81222 by major payers:
$337.61
$266.47
$430.62
$645.50
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CPT 81222
5 of 25 sample ratesHigher to lower in this preview
Chu Chen
Merrimack Valley Pediatric Associates, Inc.
$957.15Published rateChristopher Raio
Mercy Medical Center
$516.86Published rateChu Chen
Merrimack Valley Pediatric Associates, Inc.
$435.07Published rateChristopher Raio
Good Samaritan Hosptial Medical Center
$234.94Published rateE And A Medical On The Go Healthcare Of South Florida LLC, E And A Healthcare On The Go
E And A Medical On The Go Healthcare Of South Florida LLC
$152.27Published rate
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See a sample payer proposalCPT 81222 vs. Other Molecular Pathology Procedures Codes
The CPT 81222 code is part of the Pathology and Laboratory Procedures services used for Molecular Pathology Procedures. It represents a moderate-complexity encounter and is one of several codes that vary based on time spent, level of medical decision-making, and documentation requirements.
The CPT 81222 code involves more provider time and moderate medical decision-making, unlike lower-level codes that require less time and simpler assessments. It typically includes multiple diagnoses, medication management, or test interpretation, leading to higher reimbursement and more detailed documentation requirements.
| Code | Complexity | Description |
|---|---|---|
| 81220-CPT | Moderate | Cystic Fibrosis Genetic Test, A Lab Analysis Of Genetic Material That Can Indicate Cystic Fibrosis. Types Of Analysis Include Gene Variants Full Sequence Analysis Or Breakpoints. |
| 81221-CPT | Low | Cystic Fibrosis Genetic Test, A Lab Analysis Of Genetic Material That Can Indicate Cystic Fibrosis. Types Of Analysis Include Gene Variants Full Sequence Analysis Or Breakpoints. |
| 81222-CPT | Moderate | Cystic Fibrosis Genetic Test, A Lab Analysis Of Genetic Material That Can Indicate Cystic Fibrosis. Types Of Analysis Include Gene Variants Full Sequence Analysis Or Breakpoints. |
| 81223-CPT | Moderate | Cystic Fibrosis Genetic Test, A Lab Analysis Of Genetic Material That Can Indicate Cystic Fibrosis. Types Of Analysis Include Gene Variants Full Sequence Analysis Or Breakpoints. |
What is a fee schedule?
A fee schedule is a list of fixed prices that healthcare providers charge for specific services, including CPT 81222. These prices vary depending on payer type (Medicare, Medicaid, private insurance), geographic location, and provider contracts.
Understanding the 81222 fee schedule helps patients estimate costs and providers optimize billing for accurate reimbursements.
Factors that affect fee schedules
Medicare & Medicaid Rates
Government-set reimbursement amounts
Private Insurance Rates
Negotiated rates between providers and insurance companies
Geographic Location
Costs may be higher in urban areas.
Provider Type
Hospital providers may have different rates than private practice.
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