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CPT 81228 Fee Schedule

Last Verified: July 2026

Healthcare providers use this code to document and receive reimbursement for visits that address moderate-level medical decision-making, often including multiple diagnoses or prescription management.

Cytogenomic Constitutional (Genome-Wide) Microarray Analysis; Interrogation Of Genomic Regions For Copy Number Variants (Eg, Bacterial Artificial Chromosome (Bac) Or Oligo-Based Comparative Genomic Hybridization (Cgh) Microarray Analysis)
Key FactDetail
Service Type

Genetic Analysis Procedures

Tier 1 Molecular Pathology Procedures

Common Place of Service

11 - Office

81 - Independent Laboratory

Common Modifiers

None

59 - Distinct Procedural Service

90 - Reference Laboratory

XU - Unusual Non-Overlapping Service

Complexity LevelModerate
Medicare Fee ScheduleView Medicare rates for 81228

National average reimbursement for CPT 81228 by major payers:

bcbs

$656.76

uhc

$551.21

aetna

$794.18

cigna

$1,305.95

Preview provider-level rates for...
For billing codeCPT 81228
PayerCodeRateNPITax IDStateSpecialty
United
81228$360.001366400376 - SUNRISE HOME HEALTH CARE INC.650307774 - (FL) SUNRISE HOME HEALTH CARE INCFLHome Health Agency (251E00000X)
United
81228$900.001073502985 - CHU CHEN42484572 - MERRIMACK VALLEY PEDIATRIC ASSOCIATES, INC.MAPediatrics Physician (208000000X)
United
81228$378.001609823194 - SACRED HEART HEALTH SYSTEM INC, SACRED HEART HOME CARE590634434 - SACRED HEART HEALTH SYSTEM INCFLHome Health Agency (251E00000X)
United
81228$900.001073502985 - CHU CHEN42484572 - MERRIMACK VALLEY PEDIATRIC ASSOCIATES, INC.MAPediatrics Physician (208000000X)
United
81228$1080.001073576740 - MARICOPA COUNTY SPECIAL HEALTH CARE DISTRICT, VALLEYWISE HEALTH860830701AZGeneral Acute Care Hospital (282N00000X)
United
81228$540.001255478004 - CHRISTOPHER RAIO113438973 - ST JOSEPH HOSPITALNYEmergency Medicine Physician (207P00000X)
United
81228$360.001366400376 - SUNRISE HOME HEALTH CARE INC.650307774 - (FL) SUNRISE HOME HEALTH CARE INCFLHome Health Agency (251E00000X)
United
81228$1203.171528199890 - MOUNTAINSIDE FAMILY PRACTICE ASSOCIATES521958352 - ATLANTIC HEALTH SYSTEM INCNJFamily Medicine Physician (207Q00000X)
United
81228$540.001497944565 - MICHAEL SHULER581076549 - ATHENS ORTHOPEDIC CLINIC, PAGAOrthopaedic Hand Surgery Physician (207XS0106X)
United
81228$1188.001255478004 - CHRISTOPHER RAIO112050523 - ST FRANCIS HOSPITALNYEmergency Medicine Physician (207P00000X)
United
81228$450.001811000177 - CHARLESTON RADIOLOGISTS PA570634747 - CHARLESTON RADIOLOGISTS, P.A.SCSingle Specialty Group (193400000X)
United
81228$378.001730106824 - NEVADA EYE CARE PROFESSIONALS LITTLE & STEIN, LTD.880316581 - NEVADA EYE CARE PROFESSIONALSNVSingle Specialty Group (193400000X)
United
81228$1188.001255478004 - CHRISTOPHER RAIO112050523 - ST FRANCIS HOSPITALNYEmergency Medicine Physician (207P00000X)
United
81228$540.001073638490 - SHARRON ACOSTA M.D.P.A.742979530 - SHARRON ACOSTA, M.D., P.A.TXOphthalmology Physician (207W00000X)
United
81228$663.701952309171 - BAYCARE HOME CARE, INC.593582520 - (FL) BAYCARE HOME CARE INCFLHome Health Agency (251E00000X)
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist

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CPT 81228 vs. Other Tier 1 Molecular Pathology Procedures Codes

The CPT 81228 code is part of the Genetic Analysis Procedures services used for Tier 1 Molecular Pathology Procedures. It represents a moderate-complexity encounter and is one of several codes that vary based on time spent, level of medical decision-making, and documentation requirements.

The CPT 81228 code involves more provider time and moderate medical decision-making, unlike lower-level codes that require less time and simpler assessments. It typically includes multiple diagnoses, medication management, or test interpretation, leading to higher reimbursement and more detailed documentation requirements.

CodeComplexityDescription
81201-CPTModerateGenetic Test For Fap, A Lab Analysis Of Genetic Material That Can Indicate The Likelihood Of Developing Polyps Followed By Colon Cancer. This Is A Condition Called Fap (Familial Adenomatous Polyposis).
81224-CPTLowCystic Fibrosis Genetic Test, A Lab Analysis Of Genetic Material That Can Indicate Cystic Fibrosis. Types Of Analysis Include Gene Variants Full Sequence Analysis Or Breakpoints.
81226-CPTModerateCyp2d6 Gene Com Variants, Cyp2d6 Cytochrome P450 Family 2 Subfamily D Polypeptide 6 Eg Drug Metabolism Gene Analysis Common Variants Eg 2 3 4 5 6 9 10 17 19 29 35 41 1xn 2xn 4xn
81228-CPTModerateCytogenomic Constitutional (Genome-Wide) Microarray Analysis; Interrogation Of Genomic Regions For Copy Number Variants (Eg, Bacterial Artificial Chromosome (Bac) Or Oligo-Based Comparative Genomic Hybridization (Cgh) Microarray Analysis)

What is a fee schedule?

A fee schedule is a list of fixed prices that healthcare providers charge for specific services, including CPT 81228. These prices vary depending on payer type (Medicare, Medicaid, private insurance), geographic location, and provider contracts.

Understanding the 81228 fee schedule helps patients estimate costs and providers optimize billing for accurate reimbursements.

Factors that affect fee schedules


Medicare & Medicaid Rates

Government-set reimbursement amounts


Private Insurance Rates

Negotiated rates between providers and insurance companies


Geographic Location

Costs may be higher in urban areas.


Provider Type

Hospital providers may have different rates than private practice.

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