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CPT 81251 Fee Schedule

Last Verified: November 2025

Healthcare providers use this code to document and receive reimbursement for visits that address moderate-level medical decision-making, often including multiple diagnoses or prescription management.

Gba (Glucosidase, Beta, Acid) (Eg, Gaucher Disease) Gene Analysis, Common Variants (Eg, N370s, 84gg, L444p, Ivs2+1g>A)
Key FactDetail
Service Type

Pathology and Laboratory Procedures

Molecular Pathology Procedures

Common Place of Service

81 - Independent Laboratory

11 - Office

Common Modifiers

None

59 - Distinct Procedural Service

90 - Reference Laboratory

Complexity LevelLow

National average reimbursement for CPT 81251 by major payers:

bcbs

$44.30

uhc

$28.96

aetna

$61.29

cigna

$101.57

Preview provider-level rates for...
For billing codeCPT 81251
PayerCodeRateNPITax IDStateSpecialty

Select a payer to view fee schedule data

Choose a payer from the options above to see rates for CPT 81251

United
81251$137.131295791218 - PATRICIA AOUN274803222 - CITY OF HOPE MEDICAL FOUNDATIONCAMolecular Genetic Pathology (Pathology) Physician (207ZP0007X)
United
81251$59.061972034841 - DAVID BLAIR943281666CAClinical Genetics (M.D.) Physician (207SG0201X)
United
81251$49.611659559516 - ERIC MULLER260089066CAClinical Genetics (M.D.) Physician (207SG0201X)
United
81251$233.361407402597 - LAUREN BOWLING943281657CAGenetic Counselor (M.S.) (170300000X)
United
81251$59.061659559516 - ERIC MULLER260089066CAClinical Genetics (M.D.) Physician (207SG0201X)
United
81251$233.361780818302 - NIKKI MADSON943281666CAGenetic Counselor (M.S.) (170300000X)
United
81251$233.361972034841 - DAVID BLAIR943281666CAClinical Genetics (M.D.) Physician (207SG0201X)
United
81251$233.361700425196 - LAURA CARDOSO943281662CAGenetic Counselor (M.S.) (170300000X)
United
81251$49.611194701250 - VINAYA MURTHY943281660CAGenetic Counselor (M.S.) (170300000X)
United
81251$49.611780818302 - NIKKI MADSON943281666CAGenetic Counselor (M.S.) (170300000X)
United
81251$259.291780818302 - NIKKI MADSON943281666CAGenetic Counselor (M.S.) (170300000X)
United
81251$47.251215121132 - OPHIR KLEIN943191703CAClinical Genetics (M.D.) Physician (207SG0201X)
United
81251$52.911043328149 - CYNTHIA CURRY942480127CAClinical Genetics (M.D.) Physician (207SG0201X)
United
81251$63.061831403211 - HIND AL SAIF541581185 - MCV ASSOCIATED PHYSICIANSCAClinical Genetics (M.D.) Physician (207SG0201X)
United
81251$76.621326643511 - HAYLEY WRIGHT260089066CAGenetic Counselor (M.S.) (170300000X)
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist

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CPT 81251 vs. Other Molecular Pathology Procedures Codes

The CPT 81251 code is part of the Pathology and Laboratory Procedures services used for Molecular Pathology Procedures. It represents a moderate-complexity encounter and is one of several codes that vary based on time spent, level of medical decision-making, and documentation requirements.

The CPT 81251 code involves more provider time and moderate medical decision-making, unlike lower-level codes that require less time and simpler assessments. It typically includes multiple diagnoses, medication management, or test interpretation, leading to higher reimbursement and more detailed documentation requirements.

CodeComplexityDescription
81248-CPTModerateG6pd (Glucose-6-Phosphate Dehydrogenase) (Eg, Hemolytic Anemia, Jaundice), Gene Analysis; Known Familial Variant(S)
81249-CPTModerateG6pd (Glucose-6-Phosphate Dehydrogenase) (Eg, Hemolytic Anemia, Jaundice), Gene Analysis; Full Gene Sequence
81250-CPTLowG6pc (Glucose-6-Phosphatase, Catalytic Subunit) (Eg, Glycogen Storage Disease, Type 1a, Von Gierke Disease) Gene Analysis, Common Variants (Eg, R83c, Q347x)
81251-CPTLowGba (Glucosidase, Beta, Acid) (Eg, Gaucher Disease) Gene Analysis, Common Variants (Eg, N370s, 84gg, L444p, Ivs2+1g>A)

What is a fee schedule?

A fee schedule is a list of fixed prices that healthcare providers charge for specific services, including CPT 81251. These prices vary depending on payer type (Medicare, Medicaid, private insurance), geographic location, and provider contracts.

Understanding the 81251 fee schedule helps patients estimate costs and providers optimize billing for accurate reimbursements.

Factors that affect fee schedules


Medicare & Medicaid Rates

Government-set reimbursement amounts


Private Insurance Rates

Negotiated rates between providers and insurance companies


Geographic Location

Costs may be higher in urban areas.


Provider Type

Hospital providers may have different rates than private practice.

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