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CPT 81315 Fee Schedule

Last Verified: January 2026

Healthcare providers use this code to document and receive reimbursement for visits that address moderate-level medical decision-making, often including multiple diagnoses or prescription management.

Pml/Raralpha, (T(15;17)), (Promyelocytic Leukemia/Retinoic Acid Receptor Alpha) (Eg, Promyelocytic Leukemia) Translocation Analysis; Common Breakpoints (Eg, Intron 3 And Intron 6), Qualitative Or Quantitative
Key FactDetail
Service Type

Pathology and Laboratory Procedures

Molecular Pathology Procedures

Common Place of Service

81 - Independent Laboratory

22 - On Campus Outpatient Hospital

Common Modifiers

None

90 - Reference Laboratory

26 - Professional component

Complexity LevelLow
Medicare Fee ScheduleView Medicare rates for 81315

National average reimbursement for CPT 81315 by major payers:

bcbs

$174.35

uhc

$148.45

aetna

$201.56

cigna

$334.66

Preview provider-level rates for...
For billing codeCPT 81315
PayerCodeRateNPITax IDStateSpecialty

Select a payer to view fee schedule data

Choose a payer from the options above to see rates for CPT 81315

United
81315$186.581114473212 - PRISMA HEALTH-UPSTATE, PRISMA HEALTH CANCER INST-FARIS811723202 - PRISMA HEALTH - UPSTATESCGeneral Acute Care Hospital (282N00000X)
United
81315$87.061992720791 - OMEGA HOSPITAL LLC470901008 - (LA) OMEGA HOSPITAL, LLCLAGeneral Acute Care Hospital (282N00000X)
United
81315$186.581437605532 - PRISMA HEALTH-UPSTATE, PRISMA HEALTH CENTER FOR PEDIATRIC MED811723202 - PRISMA HEALTH - UPSTATESCGeneral Acute Care Hospital (282N00000X)
United
81315$207.301487271375 - METHODIST HOSPITALS OF DALLAS, METHODIST MIDLOTHIAN MEDICAL CENTER750800661 - METHODIST HOSPITALS OF DALLASTXGeneral Acute Care Hospital (282N00000X)
United
81315$207.311073502985 - CHU CHEN42484572 - MERRIMACK VALLEY PEDIATRIC ASSOCIATES, INC.MAPediatrics Physician (208000000X)
United
81315$87.061750474516 - NORTHWEST TEXAS SURGICAL HOSPITAL, LLC, NORTHWEST TEXAS SURGERY CENTER233086987 - (TX) NORTHWEST TEXAS SURGICAL HOSPITAL LLCTXGeneral Acute Care Hospital (282N00000X)
United
81315$186.581467496802 - ST FRANCIS HOSPITAL, INC., ST. FRANCIS EASTSIDE582504530 - (SC) ST FRANCIS HOSPITAL INCSCGeneral Acute Care Hospital (282N00000X)
United
81315$207.301609807122 - SPARTANBURG MEDICAL CENTER576000934SCGeneral Acute Care Hospital (282N00000X)
United
81315$186.581467496802 - ST FRANCIS HOSPITAL, INC., ST. FRANCIS EASTSIDE582504530 - (SC) ST FRANCIS HOSPITAL INCSCGeneral Acute Care Hospital (282N00000X)
United
81315$118.791457358103 - BELLVILLE HOSPITAL DISTRICT, BELLVILLE GENERAL HOSPITAL274005511 - BELLVILLE MEDICAL CENTERTXGeneral Acute Care Hospital (282N00000X)
United
81315$207.301184911877 - VHS BROWNSVILLE HOSPITAL COMPANY LLC, VALLEY BAPTIST MEDICAL CENTER - BROWNSVILLE452663071TXGeneral Acute Care Hospital (282N00000X)
United
81315$207.301275580938 - CHCA WEST HOUSTON L P, HCA HOUSTON HEALTHCARE WEST621801363 - (TX) CHCA WEST HOUSTON L PTXGeneral Acute Care Hospital (282N00000X)
United
81315$248.771316931835 - WILBARGER COUNTY HOSPITAL DISTRICT, WILBARGER GENERAL HOSPITAL756047638 - (TX) WILBARGER GENERAL HOSPITAL EMPLOYEE BENEFIT PLANTXGeneral Acute Care Hospital (282N00000X)
United
81315$339.391598750721 - HUNT MEMORIAL HOSPITAL DISTRICT, HUNT REGIONAL751277293 - (TX) HUNT MEMORIAL HOSPITAL DISTRICTTXGeneral Acute Care Hospital (282N00000X)
United
81315$207.301962455816 - CHCA CONROE LP, CONROE REGIONAL MEDICAL CENTER621801361 - (TX) CHCA CONROE LPTXGeneral Acute Care Hospital (282N00000X)
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist

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CPT 81315 vs. Other Molecular Pathology Procedures Codes

The CPT 81315 code is part of the Pathology and Laboratory Procedures services used for Molecular Pathology Procedures. It represents a moderate-complexity encounter and is one of several codes that vary based on time spent, level of medical decision-making, and documentation requirements.

The CPT 81315 code involves more provider time and moderate medical decision-making, unlike lower-level codes that require less time and simpler assessments. It typically includes multiple diagnoses, medication management, or test interpretation, leading to higher reimbursement and more detailed documentation requirements.

CodeComplexityDescription
81292-CPTModerateMlh1 (Mutl Homolog 1, Colon Cancer, Nonpolyposis Type 2) (Eg, Hereditary Non-Polyposis Colorectal Cancer, Lynch Syndrome) Gene Analysis; Full Sequence Analysis
81306-CPTModerateNudt15 (Nudix Hydrolase 15) (Eg Drug Metabolism) Gene Analysis Common Variant(S) (Eg *2 *3 *4 *5 *6)
81311-CPTModerateNras (Neuroblastoma Ras Viral [V-Ras] Oncogene Homolog) (Eg, Colorectal Carcinoma), Gene Analysis, Variants In Exon 2 (Eg, Codons 12 And 13) And Exon 3 (Eg, Codon 61)
81315-CPTLowPml/Raralpha, (T(15;17)), (Promyelocytic Leukemia/Retinoic Acid Receptor Alpha) (Eg, Promyelocytic Leukemia) Translocation Analysis; Common Breakpoints (Eg, Intron 3 And Intron 6), Qualitative Or Quantitative

What is a fee schedule?

A fee schedule is a list of fixed prices that healthcare providers charge for specific services, including CPT 81315. These prices vary depending on payer type (Medicare, Medicaid, private insurance), geographic location, and provider contracts.

Understanding the 81315 fee schedule helps patients estimate costs and providers optimize billing for accurate reimbursements.

Factors that affect fee schedules


Medicare & Medicaid Rates

Government-set reimbursement amounts


Private Insurance Rates

Negotiated rates between providers and insurance companies


Geographic Location

Costs may be higher in urban areas.


Provider Type

Hospital providers may have different rates than private practice.

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