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See a sample rate comparisonCPT 81327 Fee Schedule
Last Verified: September 2026
Healthcare providers use this code to document and receive reimbursement for visits that address moderate-level medical decision-making, often including multiple diagnoses or prescription management.
Genetic Test For Colon Cancer, A Genetic Test Used To Screen For Colon Cancer. Types Of Analysis Include Gene Variants Full Sequence Analysis Or Breakpoints.
| Key Fact | Detail |
|---|---|
| Service Type | Pathology and Laboratory Procedures Molecular Pathology Procedures |
| Common Place of Service | 81 - Independent Laboratory 11 - Office |
| Common Modifiers | None 90 - Reference Laboratory GA - Required ABN issued and on file |
| Complexity Level | Low |
| Medicare Fee Schedule | View Medicare rates for 81327 |
| Medicaid Fee Schedule | View Medicaid rates for 81327 |
National average reimbursement for CPT 81327 by major payers:
$158.14
$87.06
$163.56
$284.49
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CPT 81327
5 of 25 sample ratesHigher to lower in this preview
Christopher Raio
Mercy Medical Center
$253.44Published rateChu Chen
Merrimack Valley Pediatric Associates, Inc.
$192.00Published rateChristopher Raio
Mercy Medical Center
$115.20Published rateProgressive Medical Center Sc
Progressive Medical Center, S.C.
$80.63Published rateSunrise Home Health Care Inc.
Sunrise Home Health Care Inc
$33.47Published rate
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Payer Contract Negotiation
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See a sample payer proposalCPT 81327 vs. Other Molecular Pathology Procedures Codes
The CPT 81327 code is part of the Pathology and Laboratory Procedures services used for Molecular Pathology Procedures. It represents a moderate-complexity encounter and is one of several codes that vary based on time spent, level of medical decision-making, and documentation requirements.
The CPT 81327 code involves more provider time and moderate medical decision-making, unlike lower-level codes that require less time and simpler assessments. It typically includes multiple diagnoses, medication management, or test interpretation, leading to higher reimbursement and more detailed documentation requirements.
| Code | Complexity | Description |
|---|---|---|
| 81292-CPT | Moderate | Mlh1 (Mutl Homolog 1 Colon Ca, Mlh1 (Mutl Homolog 1 Colon Cancer Nonpolyposis Type 2) (Eg Hereditary Non-Polyposis Colorectal Cancer Lynch Syndrome) Gene Analysis Full Sequenceanalysis |
| 81327-CPT | Low | Genetic Test For Colon Cancer, A Genetic Test Used To Screen For Colon Cancer. Types Of Analysis Include Gene Variants Full Sequence Analysis Or Breakpoints. |
| 81328-CPT | Low | Genetic Test For Drug Therapy, A Lab Test That Evaluates How Well A Drug Is Metabolized By The Body. This Helps To Identify The Most Effective Drug Therapy And The Likelihood Of Developing Severe Side Effects. |
| 81329-CPT | Low | Smn1 Gene Dos Deletion Alys, Smn1 Survival Of Motor Neuron 1 Telomeric Eg Spinal Muscular Atrophy Gene Analysis Dosage Deletion Analysis Eg Carrier Testing Includes Smn2 Survival Of Motor Neuron 2 Centromeric Analysis If Performed |
What is a fee schedule?
A fee schedule is a list of fixed prices that healthcare providers charge for specific services, including CPT 81327. These prices vary depending on payer type (Medicare, Medicaid, private insurance), geographic location, and provider contracts.
Understanding the 81327 fee schedule helps patients estimate costs and providers optimize billing for accurate reimbursements.
Factors that affect fee schedules
Medicare & Medicaid Rates
Government-set reimbursement amounts
Private Insurance Rates
Negotiated rates between providers and insurance companies
Geographic Location
Costs may be higher in urban areas.
Provider Type
Hospital providers may have different rates than private practice.
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