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See a sample rate comparisonHealthcare providers use this code to document and receive reimbursement for visits that address moderate-level medical decision-making, often including multiple diagnoses or prescription management.
| Key Fact | Detail |
|---|---|
| Service Type | Pathology and Laboratory Procedures Molecular Pathology Procedures |
| Common Place of Service | 81 - Independent Laboratory 22 - On Campus Outpatient Hospital |
| Common Modifiers | None GZ - Item or Service Expected to Be Denied as Not Reasonable and Necessary XE - Separate encounter |
| Complexity Level | Low |
| Medicare Fee Schedule | View Medicare rates for 81340 |
| Medicaid Fee Schedule | View Medicaid rates for 81340 |
National average reimbursement for CPT 81340 by major payers:

$177.22

$149.75

$213.53

$324.55
Choose a payer to see a sample of rates for CPT 81340.
Atlantic Health System Inc
H Lee Moffitt Cancer Ctr & Res Inst Life Time Cancer Scrn Ctr Inc
H Lee Moffitt Cancer Ctr & Res Inst Life Time Cancer Scrn Ctr Inc
H Lee Moffitt Cancer Ctr & Res Inst Life Time Cancer Scrn Ctr Inc
E And A Medical On The Go Healthcare Of South Florida LLC
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Rate Benchmarking
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See a sample rate comparisonPayer Contract Negotiation
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See a sample payer proposalCPT 81340 vs. Other Molecular Pathology Procedures Codes
The CPT 81340 code is part of the Pathology and Laboratory Procedures services used for Molecular Pathology Procedures. It represents a moderate-complexity encounter and is one of several codes that vary based on time spent, level of medical decision-making, and documentation requirements.
The CPT 81340 code involves more provider time and moderate medical decision-making, unlike lower-level codes that require less time and simpler assessments. It typically includes multiple diagnoses, medication management, or test interpretation, leading to higher reimbursement and more detailed documentation requirements.
| Code | Complexity | Description |
|---|---|---|
| 81339-CPT | Low | Bone Marrow Genetic Test, A Lab Analysis Of Genetic Material That Can Indicate A Problem With How Bone Marrow Creates Blood Cells. Types Of Analysis Include Gene Variants Full Sequence Analysis Or Breakpoints. |
| 81340-CPT | Low | Trb Gene Rearrange Amplify, Trb T Cell Antigen Receptor Beta Eg Leukemia And Lymphoma Gene Rearrangement Analysis To Detect Abnormal Clonal Population S Using Amplification Methodology Eg Polymerase Chain Reaction |
| 81341-CPT | Low | Trb Gene Rearrange Dirprobe, Trb T Cell Antigen Receptor Beta Eg Leukemia And Lymphoma Gene Rearrangement Analysis To Detect Abnormal Clonal Population S Using Direct Probe Methodology Eg Southern Blot |
What is a fee schedule?
A fee schedule is a list of fixed prices that healthcare providers charge for specific services, including CPT 81340. These prices vary depending on payer type (Medicare, Medicaid, private insurance), geographic location, and provider contracts.
Understanding the 81340 fee schedule helps patients estimate costs and providers optimize billing for accurate reimbursements.
Factors that affect fee schedules
Medicare & Medicaid Rates
Government-set reimbursement amounts
Private Insurance Rates
Negotiated rates between providers and insurance companies
Geographic Location
Costs may be higher in urban areas.
Provider Type
Hospital providers may have different rates than private practice.
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