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CPT 81346 Fee Schedule

Last Verified: August 2026

Healthcare providers use this code to document and receive reimbursement for visits that address moderate-level medical decision-making, often including multiple diagnoses or prescription management.

Genetic Test For Drug Therapy, A Lab Test That Evaluates How Well A Drug Is Metabolized By The Body. This Helps To Identify The Most Effective Drug Therapy And The Likelihood Of Developing Severe Side Effects.
Key FactDetail
Service Type

Pathology and Laboratory Procedures

Molecular Pathology Procedures

Common Place of Service

81 - Independent Laboratory

11 - Office

Common Modifiers

None

59 - Distinct Procedural Service

90 - Reference Laboratory

Complexity LevelLow
Medicare Fee ScheduleView Medicare rates for 81346

National average reimbursement for CPT 81346 by major payers:

bcbs

$159.53

uhc

$107.14

aetna

$160.03

cigna

$261.11

Preview provider-level rates for...
For billing codeCPT 81346
PayerCodeRateNPITax IDStateSpecialty
United
81346$192.291366428401 - AARON ASKEW931224010 - PRAXIS HEALTH, P.C.OROrthopaedic Trauma Physician (207XX0801X)
United
81346$174.811073502985 - CHU CHEN42484572 - MERRIMACK VALLEY PEDIATRIC ASSOCIATES, INC.MAPediatrics Physician (208000000X)
United
81346$139.851255766531 - MARISSA LIVERIS362925195 - ALLERGY & ASTHMA OF DUPAGE, S.C.ILPhysician Assistant (363A00000X)
United
81346$175.081053391094 - ASYA SEGALENE362925195 - ALLERGY & ASTHMA OF DUPAGE, S.C.ILAllergy Physician (207KA0200X)
United
81346$230.751255478004 - CHRISTOPHER RAIO111635088 - MERCY MEDICAL CENTERNYEmergency Medicine Physician (207P00000X)
United
81346$128.911013915149 - BAYCARE HOME CARE, INC., DBA SARASOTA MEMORIAL HOME CARE593582520 - (FL) BAYCARE HOME CARE INCFLHome Health Agency (251E00000X)
United
81346$207.671255478004 - CHRISTOPHER RAIO113438973 - ST JOSEPH HOSPITALNYEmergency Medicine Physician (207P00000X)
United
81346$128.911821097627 - BAYCARE HOME CARE, INC.593582520 - (FL) BAYCARE HOME CARE INCFLHome Health Agency (251E00000X)
United
81346$73.421730106824 - NEVADA EYE CARE PROFESSIONALS LITTLE & STEIN, LTD.880316581 - NEVADA EYE CARE PROFESSIONALSNVSingle Specialty Group (193400000X)
United
81346$94.401255478004 - CHRISTOPHER RAIO112050523 - ST FRANCIS HOSPITALNYEmergency Medicine Physician (207P00000X)
United
81346$104.891255478004 - CHRISTOPHER RAIO111888924 - GOOD SAMARITAN HOSPTIAL MEDICAL CENTERNYEmergency Medicine Physician (207P00000X)
United
81346$384.581073502985 - CHU CHEN42484572 - MERRIMACK VALLEY PEDIATRIC ASSOCIATES, INC.MAPediatrics Physician (208000000X)
United
81346$104.891073638490 - SHARRON ACOSTA M.D.P.A.742979530 - SHARRON ACOSTA, M.D., P.A.TXOphthalmology Physician (207W00000X)
United
81346$73.411386965267 - RENAL CONSULTANTS MEDICAL GROUP953841576 - (CA) RENAL CONSULTANTS MEDICAL GROUPCANephrology Physician (207RN0300X)
United
81346$96.151144370990 - ROLANDO HENRIQUEZ363950044 - PROGRESSIVE MEDICAL CENTER, S.C.ILInternal Medicine Physician (207R00000X)
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist

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CPT 81346 vs. Other Molecular Pathology Procedures Codes

The CPT 81346 code is part of the Pathology and Laboratory Procedures services used for Molecular Pathology Procedures. It represents a moderate-complexity encounter and is one of several codes that vary based on time spent, level of medical decision-making, and documentation requirements.

The CPT 81346 code involves more provider time and moderate medical decision-making, unlike lower-level codes that require less time and simpler assessments. It typically includes multiple diagnoses, medication management, or test interpretation, leading to higher reimbursement and more detailed documentation requirements.

CodeComplexityDescription
81345-CPTLowTert Gene Targeted Seq Alys, Tert Telomerase Reverse Transcriptase Eg Thyroid Carcinoma Glioblastoma Multiforme Gene Analysis Targeted Sequence Analysis Eg Promoter Region
81346-CPTLowGenetic Test For Drug Therapy, A Lab Test That Evaluates How Well A Drug Is Metabolized By The Body. This Helps To Identify The Most Effective Drug Therapy And The Likelihood Of Developing Severe Side Effects.
81347-CPTLowSf3b1 Gene Common Variants, Sf3b1 Splicing Factor 3b Subunit B1 Eg Myelodysplastic Syndrome Acute Myeloid Leukemia Gene Analysis Common Variants Eg A672t E622d L833f R625c R625l

What is a fee schedule?

A fee schedule is a list of fixed prices that healthcare providers charge for specific services, including CPT 81346. These prices vary depending on payer type (Medicare, Medicaid, private insurance), geographic location, and provider contracts.

Understanding the 81346 fee schedule helps patients estimate costs and providers optimize billing for accurate reimbursements.

Factors that affect fee schedules


Medicare & Medicaid Rates

Government-set reimbursement amounts


Private Insurance Rates

Negotiated rates between providers and insurance companies


Geographic Location

Costs may be higher in urban areas.


Provider Type

Hospital providers may have different rates than private practice.

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