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CPT 81415 Fee Schedule

Last Verified: September 2026

Healthcare providers use this code to document and receive reimbursement for visits that address high-level medical decision-making, often including multiple diagnoses or prescription management.

Key FactDetail
Service Type

Pathology and Laboratory Procedures

Genomic Sequencing Procedures and Other Molecular Multianalyte Assays

Common Place of Service

81 - Independent Laboratory

11 - Office

Common Modifiers

None

59 - Distinct Procedural Service

90 - Reference Laboratory

Complexity LevelHigh
Medicare Fee ScheduleView Medicare rates for 81415
Medicaid Fee ScheduleView Medicaid rates for 81415

National average reimbursement for CPT 81415 by major payers:

bcbs

$3,531.62

uhc

$2,927.76

aetna

$4,188.34

cigna

$6,597.40

CPT 81415 vs. Other Genomic Sequencing Procedures and Other Molecular Multianalyte Assays Codes

The CPT 81415 code is part of the Pathology and Laboratory Procedures services used for Genomic Sequencing Procedures and Other Molecular Multianalyte Assays. It represents a moderate-complexity encounter and is one of several codes that vary based on time spent, level of medical decision-making, and documentation requirements.

The CPT 81415 code involves more provider time and moderate medical decision-making, unlike lower-level codes that require less time and simpler assessments. It typically includes multiple diagnoses, medication management, or test interpretation, leading to higher reimbursement and more detailed documentation requirements.

CodeComplexityDescription
81415-CPTHigh
Exome (Eg Unexplaind Constituti Or Heritable Disord Or Syndro, Exome (Eg Unexplained Constitutional Or Heritable Disorder Or Syndrom
81416-CPTHigh
Exome (Eg Unexplained Constit, Exome (Eg Unexplained Constitutional Or Heritabledisorder Or Syndrome) Sequence Analysis Each Co Mparator Exome (Eg Parents Siblings) (List Separately In Addition To Code For Primary Procedure)
81417-CPTModerate
Exome (Eg Unexplained Constit, Exome (Eg Unexplained Constitutional Or Heritabledisorder Or Syndrome) Re-Evaluation Of Previousl Y Obtained Exome Sequence (Eg Updated Knowledge Or Unrelated Conditionsyndrome)
81425-CPTHigh
Genom (Eg Unexplaind Constituti Or Heritable Disord Or Syndro, Genome (Eg Unexplained Constitutional Or Heritable Disorder Or Syndro

What is a fee schedule?

A fee schedule is a list of fixed prices that healthcare providers charge for specific services, including CPT 81415. These prices vary depending on payer type (Medicare, Medicaid, private insurance), geographic location, and provider contracts.

Understanding the 81415 fee schedule helps patients estimate costs and providers optimize billing for accurate reimbursements.

Factors that affect fee schedules


Medicare & Medicaid Rates

Government-set reimbursement amounts


Private Insurance Rates

Negotiated rates between providers and insurance companies


Geographic Location

Costs may be higher in urban areas.


Provider Type

Hospital providers may have different rates than private practice.

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