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CPT 81450 Fee Schedule

Last Verified: December 2025

Healthcare providers use this code to document and receive reimbursement for visits that address moderate-level medical decision-making, often including multiple diagnoses or prescription management.

Targeted Genomic Sequence Analysis Panel Hematolymphoid Neoplasm Or Disorder 5-50 Genes (Eg Braf Cebpa Dnmt3a Ezh2 Flt3 Idh1 Idh2 Jak2 Kit Kras Mll Notch1 Npm1 Nras) Interrogation For Sequence Variants And Copy Number Variants Or Rearrangements Or Isoform Expression Or Mrna Expression Levels If Performed; Dna Analysis Or Combined Dna And Rna Analysis (Desc Rvsd 1/1/23)
Key FactDetail
Service Type

Pathology and Laboratory Procedures

Genomic Sequencing Procedures and Other Molecular Multianalyte Assays

Common Place of Service

81 - Independent Laboratory

11 - Office

Common Modifiers

None

PO - Services, procedures and/or surgeries furnished at off-campus provider-based outpatient departments

59 - Distinct Procedural Service

Complexity LevelModerate

National average reimbursement for CPT 81450 by major payers:

bcbs

$585.76

uhc

$322.11

aetna

$731.54

cigna

$1,102.33

Preview provider-level rates for...
For billing codeCPT 81450
PayerCodeRateNPITax IDStateSpecialty

Select a payer to view fee schedule data

Choose a payer from the options above to see rates for CPT 81450

United
81450$319.001649223645 - ST DAVIDS HEALTHCARE PARTNERSHIP LP LLP, ROUND ROCK MEDICAL CENTER743001674 - (TX) LONE STAR CIRCLE OF CARETXGeneral Acute Care Hospital (282N00000X)
United
81450$273.421568848059 - CUMBERLAND SURGICAL HOSPITAL OF SAN ANTONIO LLC, LEGENT ORTHOPEDIC & SPINE474612520TXGeneral Acute Care Hospital (282N00000X)
United
81450$759.531861467573 - THE MEDICAL CENTER OF SOUTHEAST TEXAS LP270060569 - (TX) THE MEDICAL CENTER OF SOUTHEAST TEXAS LPTXGeneral Acute Care Hospital (282N00000X)
United
81450$53.901972590602 - PALO PINTO COUNTY HOSPITAL DISTRICT, PALO PINTO GENERAL HOSPITAL751256948TXGeneral Acute Care Hospital (282N00000X)
United
81450$80.841396394961 - CLHG-ACADIAN, LLC, ACADIAN MEDICAL CENTER825359949LAGeneral Acute Care Hospital (282N00000X)
United
81450$759.531447230388 - OPELOUSAS GENERAL HOSPITAL AUTHORITY720708111LAGeneral Acute Care Hospital (282N00000X)
United
81450$759.531275506115 - SPRINGHILL MEDICAL SERVICES, INC., SPRINGHILL MEDICAL CENTER721479692 - SPRINGHILL MEDICAL SERVICES INCLAGeneral Acute Care Hospital (282N00000X)
United
81450$911.441174526529 - TITUS COUNTY HOSPITAL DISTRICT, TITUS REGIONAL MEDICAL CENTER756003935TXGeneral Acute Care Hospital (282N00000X)
United
81450$759.531598766495 - OUR LADY OF LOURDES REGIONAL MEDICAL CENTER,INC720423635 - OUR LADY OF LOURDES REGIONAL MEDICAL CENTER INCLAGeneral Acute Care Hospital (282N00000X)
United
81450$80.841497792527 - UNIVERSITY HEALTHCARE SYSTEM, L.C., TULANE LAKESIDE HOSPITAL843390470 - (LA) LCMC HEALTH HOLDINGS INCLAGeneral Acute Care Hospital (282N00000X)
United
81450$95.221033168786 - HOUSTON VAMC760418077TXGeneral Acute Care Hospital (282N00000X)
United
81450$80.841396394961 - CLHG-ACADIAN, LLC, ACADIAN MEDICAL CENTER825359949LAGeneral Acute Care Hospital (282N00000X)
United
81450$759.531962455816 - CHCA CONROE LP, CONROE REGIONAL MEDICAL CENTER621801361 - (TX) CHCA CONROE LPTXGeneral Acute Care Hospital (282N00000X)
United
81450$319.001942294939 - ST JOSEPH REGIONAL HEALTH CENTER, ST JOSEPH AMBULATORY SURGERY741282696 - ST JOSEPH REGIONAL HEALTH CENTERTXGeneral Acute Care Hospital (282N00000X)
United
81450$759.531003344334 - HCN EP HORIZON CITY, LLC, THE HOSPITALS OF PROVIDENCE HORIZON CITY CAMPUS813935393 - (TX) HCN EP HORIZON CITY LLCTXGeneral Acute Care Hospital (282N00000X)
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist

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CPT 81450 vs. Other Genomic Sequencing Procedures and Other Molecular Multianalyte Assays Codes

The CPT 81450 code is part of the Pathology and Laboratory Procedures services used for Genomic Sequencing Procedures and Other Molecular Multianalyte Assays. It represents a moderate-complexity encounter and is one of several codes that vary based on time spent, level of medical decision-making, and documentation requirements.

The CPT 81450 code involves more provider time and moderate medical decision-making, unlike lower-level codes that require less time and simpler assessments. It typically includes multiple diagnoses, medication management, or test interpretation, leading to higher reimbursement and more detailed documentation requirements.

CodeComplexityDescription
81445-CPTModerateTargeted Genomic Sequence Analysis Panel Solid Organ Neoplasm 5-50 Genes (Eg Alk Braf Cdkn2a Egfr Erbb2 Kit Kras Met Nras Pdgfra Pdgfrb Pgr Pik3ca Pten Ret) Interrogation For Sequence Variants And Copy Number Variants Or Rearrangements If Performed; Dna Analysis Or Combined Dna And Rna Analysis (Desc Rvsd 1/1/23)
81449-CPTModerateTargeted Genomic Sequence Analysis Panel, Solid Organ Neoplasm, 5-50 Genes (Eg, Alk, Braf, Cdkn2a, Egfr, Erbb2, Kit, Kras, Met, Nras, Pdgfra, Pdgfrb, Pgr, Pik3ca, Pten, Ret), Interrogation For Sequence Variants And Copy Number Variants Or Rearrangements, If Performed; Rna Analysis
81450-CPTModerateTargeted Genomic Sequence Analysis Panel Hematolymphoid Neoplasm Or Disorder 5-50 Genes (Eg Braf Cebpa Dnmt3a Ezh2 Flt3 Idh1 Idh2 Jak2 Kit Kras Mll Notch1 Npm1 Nras) Interrogation For Sequence Variants And Copy Number Variants Or Rearrangements Or Isoform Expression Or Mrna Expression Levels If Performed; Dna Analysis Or Combined Dna And Rna Analysis (Desc Rvsd 1/1/23)
81451-CPTModerateTargeted Genomic Sequence Analysis Panel, Hematolymphoid Neoplasm Or Disorder, 5-50 Genes (Eg, Braf, Cebpa, Dnmt3a, Ezh2, Flt3, Idh1, Idh2, Jak2, Kit, Kras, Mll, Notch1, Npm1, Nras), Interrogation For Sequence Variants, And Copy Number Variants Or Rearrangements, Or Isoform Expression Or Mrna Expression Levels, If Performed; Rna Analysis

What is a fee schedule?

A fee schedule is a list of fixed prices that healthcare providers charge for specific services, including CPT 81450. These prices vary depending on payer type (Medicare, Medicaid, private insurance), geographic location, and provider contracts.

Understanding the 81450 fee schedule helps patients estimate costs and providers optimize billing for accurate reimbursements.

Factors that affect fee schedules


Medicare & Medicaid Rates

Government-set reimbursement amounts


Private Insurance Rates

Negotiated rates between providers and insurance companies


Geographic Location

Costs may be higher in urban areas.


Provider Type

Hospital providers may have different rates than private practice.

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