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CPT 81450 Fee Schedule

Last Verified: January 2026

Healthcare providers use this code to document and receive reimbursement for visits that address moderate-level medical decision-making, often including multiple diagnoses or prescription management.

Targeted Genomic Sequence Analysis Panel Hematolymphoid Neoplasm Or Disorder 5-50 Genes (Eg Braf Cebpa Dnmt3a Ezh2 Flt3 Idh1 Idh2 Jak2 Kit Kras Mll Notch1 Npm1 Nras) Interrogation For Sequence Variants And Copy Number Variants Or Rearrangements Or Isoform Expression Or Mrna Expression Levels If Performed; Dna Analysis Or Combined Dna And Rna Analysis (Desc Rvsd 1/1/23)
Key FactDetail
Service Type

Pathology and Laboratory Procedures

Genomic Sequencing Procedures and Other Molecular Multianalyte Assays

Common Place of Service

81 - Independent Laboratory

11 - Office

Common Modifiers

None

PO - Services, procedures and/or surgeries furnished at off-campus provider-based outpatient departments

59 - Distinct Procedural Service

Complexity LevelModerate
Medicare Fee ScheduleView Medicare rates for 81450

National average reimbursement for CPT 81450 by major payers:

bcbs

$585.76

uhc

$322.11

aetna

$731.54

cigna

$1,102.33

Preview provider-level rates for...
For billing codeCPT 81450
PayerCodeRateNPITax IDStateSpecialty

Select a payer to view fee schedule data

Choose a payer from the options above to see rates for CPT 81450

United
81450$95.221922058569 - SAN ANTONIO VAMC742112082TXGeneral Acute Care Hospital (282N00000X)
United
81450$911.441609807122 - SPARTANBURG MEDICAL CENTER576000934SCGeneral Acute Care Hospital (282N00000X)
United
81450$759.531568818417 - METHODIST HOSPITALS OF DALLAS, METHODIST SOUTHLAKE MEDICAL CENTER750800661 - METHODIST HOSPITALS OF DALLASTXGeneral Acute Care Hospital (282N00000X)
United
81450$759.531811942238 - KPH-CONSOLIDATION, INC., HCA HOUSTON HEALTHCARE NORTH CYPRESS A CAMPUS OF HCA HOUSTON HEALTHCAR621619857TXGeneral Acute Care Hospital (282N00000X)
United
81450$759.531003344334 - HCN EP HORIZON CITY, LLC, THE HOSPITALS OF PROVIDENCE HORIZON CITY CAMPUS813935393 - (TX) HCN EP HORIZON CITY LLCTXGeneral Acute Care Hospital (282N00000X)
United
81450$759.531003898313 - MOREHOUSE GENERAL HOSPITAL726011528 - (LA) MOREHOUSE GENERAL HOSPITALLAGeneral Acute Care Hospital (282N00000X)
United
81450$272.321174526529 - TITUS COUNTY HOSPITAL DISTRICT, TITUS REGIONAL MEDICAL CENTER756003935TXGeneral Acute Care Hospital (282N00000X)
United
81450$759.531962455816 - CHCA CONROE LP, CONROE REGIONAL MEDICAL CENTER621801361 - (TX) CHCA CONROE LPTXGeneral Acute Care Hospital (282N00000X)
United
81450$759.531598766495 - OUR LADY OF LOURDES REGIONAL MEDICAL CENTER,INC720423635 - OUR LADY OF LOURDES REGIONAL MEDICAL CENTER INCLAGeneral Acute Care Hospital (282N00000X)
United
81450$759.531003925959 - HOSPITAL SERVICE DISTRICT 2 OF THE PARISH OF TANGIPAHOA STATE OF LA., HOOD MEMORIAL HOSPITAL720694946 - (LA) HOSPITAL SERVICE DISTRICT 2 OF THE PARISH OF TANGIPAHOA STATE OF LALACritical Access Hospital (282NC0060X)
United
81450$759.531508810573 - BAY AREA HEALTHCARE GROUP, LTD., CORPUS CHRISTI MEDICAL CENTER752387418TXGeneral Acute Care Hospital (282N00000X)
United
81450$759.531649223645 - ST DAVIDS HEALTHCARE PARTNERSHIP LP LLP, ROUND ROCK MEDICAL CENTER742781812TXGeneral Acute Care Hospital (282N00000X)
United
81450$53.901871599829 - WILSON COUNTY MEMORIAL HOSPITAL DISTRICT742019736 - (TX) WILSON COUNTY MEMORIAL HOSPITAL DISTRICTTXGeneral Acute Care Hospital (282N00000X)
United
81450$80.841265437644 - WEST JEFFERSON HOLDINGS, LLC, WEST JEFFERSON MEDICAL CENTER472667968 - WEST JEFFERSON HOLDINGS, LLCLAGeneral Acute Care Hospital (282N00000X)
United
81450$759.531841843455 - HCN EP HORIZON CITY, LLC, THE HOSPITALS OF PROVIDENCE EMERGENCY ROOM MONTWOOD813935393 - (TX) HCN EP HORIZON CITY LLCTXGeneral Acute Care Hospital (282N00000X)
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist

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CPT 81450 vs. Other Genomic Sequencing Procedures and Other Molecular Multianalyte Assays Codes

The CPT 81450 code is part of the Pathology and Laboratory Procedures services used for Genomic Sequencing Procedures and Other Molecular Multianalyte Assays. It represents a moderate-complexity encounter and is one of several codes that vary based on time spent, level of medical decision-making, and documentation requirements.

The CPT 81450 code involves more provider time and moderate medical decision-making, unlike lower-level codes that require less time and simpler assessments. It typically includes multiple diagnoses, medication management, or test interpretation, leading to higher reimbursement and more detailed documentation requirements.

CodeComplexityDescription
81445-CPTModerateTargeted Genomic Sequence Analysis Panel Solid Organ Neoplasm 5-50 Genes (Eg Alk Braf Cdkn2a Egfr Erbb2 Kit Kras Met Nras Pdgfra Pdgfrb Pgr Pik3ca Pten Ret) Interrogation For Sequence Variants And Copy Number Variants Or Rearrangements If Performed; Dna Analysis Or Combined Dna And Rna Analysis (Desc Rvsd 1/1/23)
81449-CPTModerateTargeted Genomic Sequence Analysis Panel, Solid Organ Neoplasm, 5-50 Genes (Eg, Alk, Braf, Cdkn2a, Egfr, Erbb2, Kit, Kras, Met, Nras, Pdgfra, Pdgfrb, Pgr, Pik3ca, Pten, Ret), Interrogation For Sequence Variants And Copy Number Variants Or Rearrangements, If Performed; Rna Analysis
81450-CPTModerateTargeted Genomic Sequence Analysis Panel Hematolymphoid Neoplasm Or Disorder 5-50 Genes (Eg Braf Cebpa Dnmt3a Ezh2 Flt3 Idh1 Idh2 Jak2 Kit Kras Mll Notch1 Npm1 Nras) Interrogation For Sequence Variants And Copy Number Variants Or Rearrangements Or Isoform Expression Or Mrna Expression Levels If Performed; Dna Analysis Or Combined Dna And Rna Analysis (Desc Rvsd 1/1/23)
81451-CPTModerateTargeted Genomic Sequence Analysis Panel, Hematolymphoid Neoplasm Or Disorder, 5-50 Genes (Eg, Braf, Cebpa, Dnmt3a, Ezh2, Flt3, Idh1, Idh2, Jak2, Kit, Kras, Mll, Notch1, Npm1, Nras), Interrogation For Sequence Variants, And Copy Number Variants Or Rearrangements, Or Isoform Expression Or Mrna Expression Levels, If Performed; Rna Analysis

What is a fee schedule?

A fee schedule is a list of fixed prices that healthcare providers charge for specific services, including CPT 81450. These prices vary depending on payer type (Medicare, Medicaid, private insurance), geographic location, and provider contracts.

Understanding the 81450 fee schedule helps patients estimate costs and providers optimize billing for accurate reimbursements.

Factors that affect fee schedules


Medicare & Medicaid Rates

Government-set reimbursement amounts


Private Insurance Rates

Negotiated rates between providers and insurance companies


Geographic Location

Costs may be higher in urban areas.


Provider Type

Hospital providers may have different rates than private practice.

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