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CPT 81464 Fee Schedule

Last Verified: December 2025

Healthcare providers use this code to document and receive reimbursement for visits that address moderate-level medical decision-making, often including multiple diagnoses or prescription management.

Solid Organ Neoplasm, Genomic Sequence Analysis Panel, Cell-Free Nucleic Acid (Eg, Plasma), Interrogation For Sequence Variants; Dna Analysis Or Combined Dna And Rna Analysis, Copy Number Variants, Microsatellite Instability, Tumor Mutation Burden, And Rearrangements
Key FactDetail
Service Type

Pathology and Laboratory Procedures

Genomic Sequencing Procedures and Other Molecular Multianalyte Assays

Complexity LevelModerate

National average reimbursement for CPT 81464 by major payers:

bcbs

$N/A

uhc

$N/A

aetna

$N/A

cigna

$N/A

Preview provider-level rates for...
For billing codeCPT 81464
PayerCodeRateNPITax IDStateSpecialty

Select a payer to view fee schedule data

Choose a payer from the options above to see rates for CPT 81464

United
81464$1973.101629185285 - BACON COUNTY HEALTH SERVICES, INC.582224545 - (GA) BACON COUNTY HEALTH SERVICES INCGACritical Access Hospital (282NC0060X)
United
81464$3288.511467420448 - COBB HOSPITAL, INC, WELLSTAR COBB HOSPITAL580968382 - COBB HOSPITALGAGeneral Acute Care Hospital (282N00000X)
United
81464$1973.101255891958 - PIEDMONT NEWTON EKG BILLING LLC582155150 - (GA) PIEDMONT NEWTON HOSPITAL INCGAGeneral Acute Care Hospital (282N00000X)
United
81464$1973.101184771586 - LOWER OCONEE COMMUNITY HOSPITAL INC208897263GACritical Access Hospital (282NC0060X)
United
81464$5663.791598964082 - EMORY HEALTHCARE582030692 - EMORY UNIVERSITYGAGeneral Acute Care Hospital (282N00000X)
United
81464$1973.101972731800 - MERIWETHER HEALTHCARE, L.L.C., WARM SPRINGS MEDICAL CENTER870764535 - (GA) MERIWETHER HEALTHCARE, LLC D/B/A WARM SPRINGS MEDICAL CENTERGACritical Access Hospital (282NC0060X)
United
81464$1578.471760452098 - HOSPITAL AUTHORITY OF JENKINS COUNTY273100894GACritical Access Hospital (282NC0060X)
United
81464$3288.511902855216 - ATLANTA VAMC582091280GAGeneral Acute Care Hospital (282N00000X)
United
81464$1381.171174512115 - MICHAEL GUILLETTE271495988 - (NM) AZTEC URGENT CARE LLCCOPhysician Assistant (363A00000X)
United
81464$1973.101487684122 - UNION COUNTY HOSPITAL AUTHORITY, UNION GENERAL HOSPITAL586025393 - (GA) UNION COUNTY HOSPITAL AUTHORITYGAGeneral Acute Care Hospital (282N00000X)
United
81464$1973.101821017831 - BACON COUNTY HEALTH SERVICES, INC, BACON COUNTY RURAL HEALTH CLINIC582224545 - (GA) BACON COUNTY HEALTH SERVICES INCGARural Acute Care Hospital (282NR1301X)
United
81464$1973.101316938459 - NAVICENT HEALTH OCONEE, LLC, NAVICENT HEALTH BALDWIN582359398 - NAVICENT HEALTH OCONEE LLCGAGeneral Acute Care Hospital (282N00000X)
United
81464$1578.471497064679 - JENKINS COUNTY HOSPITAL LLC, OPTIM MEDICAL CENTER - JENKINS581158547 - (GA) HOSPITAL AUTHORITY OF JENKINS COUNTY DBA JENKINS COUNTY MEDICAL CENTERGACritical Access Hospital (282NC0060X)
United
81464$1381.171386965267 - RENAL CONSULTANTS MEDICAL GROUP953841576 - (CA) RENAL CONSULTANTS MEDICAL GROUPCANephrology Physician (207RN0300X)
United
81464$1381.171053515130 - MIGUEL A. ARENAS, M.D., PC300394179 - (AZ) MIGUEL A ARENAS MD PCAZGastroenterology Physician (207RG0100X)
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist

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CPT 81464 vs. Other Genomic Sequencing Procedures and Other Molecular Multianalyte Assays Codes

The CPT 81464 code is part of the Pathology and Laboratory Procedures services used for Genomic Sequencing Procedures and Other Molecular Multianalyte Assays. It represents a moderate-complexity encounter and is one of several codes that vary based on time spent, level of medical decision-making, and documentation requirements.

The CPT 81464 code involves more provider time and moderate medical decision-making, unlike lower-level codes that require less time and simpler assessments. It typically includes multiple diagnoses, medication management, or test interpretation, leading to higher reimbursement and more detailed documentation requirements.

CodeComplexityDescription
81464-CPTModerateSolid Organ Neoplasm, Genomic Sequence Analysis Panel, Cell-Free Nucleic Acid (Eg, Plasma), Interrogation For Sequence Variants; Dna Analysis Or Combined Dna And Rna Analysis, Copy Number Variants, Microsatellite Instability, Tumor Mutation Burden, And Rearrangements

What is a fee schedule?

A fee schedule is a list of fixed prices that healthcare providers charge for specific services, including CPT 81464. These prices vary depending on payer type (Medicare, Medicaid, private insurance), geographic location, and provider contracts.

Understanding the 81464 fee schedule helps patients estimate costs and providers optimize billing for accurate reimbursements.

Factors that affect fee schedules


Medicare & Medicaid Rates

Government-set reimbursement amounts


Private Insurance Rates

Negotiated rates between providers and insurance companies


Geographic Location

Costs may be higher in urban areas.


Provider Type

Hospital providers may have different rates than private practice.

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