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CPT 81490 Fee Schedule

Last Verified: October 2025

Healthcare providers use this code to document and receive reimbursement for visits that address moderate-level medical decision-making, often including multiple diagnoses or prescription management.

Autoimmune (Rheumatoid Arthritis) Analysis Of 12 Biomarkers Using Immunoassays Utilizing Serum Prognosticalgorithm Reported As A Disease Activity Score
Key FactDetail
Service Type

Pathology and Laboratory Procedures

Multianalyte Assays with Algorithmic Analyses

Common Place of Service

81 - Independent Laboratory

11 - Office

Common Modifiers

None

90 - Reference Laboratory

26 - Professional component

Complexity LevelModerate

National average reimbursement for CPT 81490 by major payers:

bcbs

$655.32

uhc

$447.65

aetna

$739.97

cigna

$1,235.72

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For billing codeCPT 81490
PayerCodeRateNPITax IDStateSpecialty

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CPT 81490 vs. Other Multianalyte Assays with Algorithmic Analyses Codes

The CPT 81490 code is part of the Pathology and Laboratory Procedures services used for Multianalyte Assays with Algorithmic Analyses. It represents a moderate-complexity encounter and is one of several codes that vary based on time spent, level of medical decision-making, and documentation requirements.

The CPT 81490 code involves more provider time and moderate medical decision-making, unlike lower-level codes that require less time and simpler assessments. It typically includes multiple diagnoses, medication management, or test interpretation, leading to higher reimbursement and more detailed documentation requirements.

CodeComplexityDescription
81490ModerateAutoimmune (Rheumatoid Arthritis) Analysis Of 12 Biomarkers Using Immunoassays Utilizing Serum Prognosticalgorithm Reported As A Disease Activity Score
81493ModerateCoronary Artery Disease, Mrna, Gene Expression Profiling By Real-Time Rt-Pcr Of 23 Genes, Utilizing Whole Peripheral Blood, Algorithm Reported As A Risk Score
81506LowEndocrinology (Type 2 Diabetes), Biochemical Assays Of Seven Analytes (Glucose, Hba1c, Insulin, Hs-Crp, Adiponectin, Ferritin, Interleukin 2-Receptor Alpha), Utilizing Serum Or Plasma, Algorithm Reporting A Risk Score
81507ModerateFetal Aneuploidy (Trisomy 21 18 And 13) Dna Sequence Analysis Of Selected Regions Using Maternal Plasma Algorithm Reported As A Risk Score For Each Trisomy

What is a fee schedule?

A fee schedule is a list of fixed prices that healthcare providers charge for specific services, including CPT 81490. These prices vary depending on payer type (Medicare, Medicaid, private insurance), geographic location, and provider contracts.

Understanding the 81490 fee schedule helps patients estimate costs and providers optimize billing for accurate reimbursements.

Factors that affect fee schedules


Medicare & Medicaid Rates

Government-set reimbursement amounts


Private Insurance Rates

Negotiated rates between providers and insurance companies


Geographic Location

Costs may be higher in urban areas.


Provider Type

Hospital providers may have different rates than private practice.

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YearBilling CodeLocalityNon-Facility FeeFacility Fee