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CPT 88280 Fee Schedule

Last Verified: July 2026

Healthcare providers use this code to document and receive reimbursement for visits that address moderate-level medical decision-making, often including multiple diagnoses or prescription management.

Additional Genetic Study, Additional Studies Of Full Chromosome Sets That Describes A Persons Genetic Makeup (Karyotypes) Beyond The Base Chromosome Analysis. Karyotypes Help To Identify And Organize Genetic Abnormalities And Can Pinpoint Diagnosis Of Certain Cancers.
Key FactDetail
Service Type

Cytogenetic Studies

Pathology and Laboratory Procedures

Common Place of Service

81 - Independent Laboratory

11 - Office

Common Modifiers

None

PO - Services, procedures and/or surgeries furnished at off-campus provider-based outpatient departments

90 - Reference Laboratory

Complexity LevelLow
Medicare Fee ScheduleView Medicare rates for 88280

National average reimbursement for CPT 88280 by major payers:

bcbs

$30.60

uhc

$28.13

aetna

$34.29

cigna

$48.14

Preview provider-level rates for...
For billing codeCPT 88280
PayerCodeRateNPITax IDStateSpecialty
United
88280$30.121659827756 - PRISMA HEALTH-UPSTATE, PRISMA HEALTH CANCER INST-GROVE811723202 - PRISMA HEALTH - UPSTATESCGeneral Acute Care Hospital (282N00000X)
United
88280$55.001649599168 - RESTORATIVE HEALTH REHABILITATION INC272533824 - (FL) RESTORATIVE HEALTH REHABILITATION INCFLHome Health Agency (251E00000X)
United
88280$20.541669480323 - KELL WEST REGIONAL HOSPITAL LLC752756307 - KELL WEST REGIONAL HOSPITAL, LLCTXGeneral Acute Care Hospital (282N00000X)
United
88280$33.471255478004 - CHRISTOPHER RAIO112050523 - ST FRANCIS HOSPITALNYEmergency Medicine Physician (207P00000X)
United
88280$30.121821760430 - PRISMA HEALTH-UPSTATE811723202 - PRISMA HEALTH - UPSTATESCGeneral Acute Care Hospital (282N00000X)
United
88280$20.081255478004 - CHRISTOPHER RAIO112050523 - ST FRANCIS HOSPITALNYEmergency Medicine Physician (207P00000X)
United
88280$33.471629021845 - ST DAVIDS HEALTHCARE PARTNERSHIP LP LLP, NORTH AUSTIN MEDICAL CENTER742781812TXGeneral Acute Care Hospital (282N00000X)
United
88280$20.941447317110 - BAPTIST HEALTH CARE, INC., BAPTIST HOME HEALT CARE AND MEDICAL EQUIPMENT590657322 - BAPTIST HEALTH CARE INCFLHome Health Agency (251E00000X)
United
88280$78.911073638490 - SHARRON ACOSTA M.D.P.A.742979530 - SHARRON ACOSTA, M.D., P.A.TXOphthalmology Physician (207W00000X)
United
88280$80.801073502985 - CHU CHEN42484572 - MERRIMACK VALLEY PEDIATRIC ASSOCIATES, INC.MAPediatrics Physician (208000000X)
United
88280$30.121821544925 - PRISMA HEALTH-UPSTATE, PRISMA HEALTH CANCER INST-SENECA811723202 - PRISMA HEALTH - UPSTATESCGeneral Acute Care Hospital (282N00000X)
United
88280$20.511366428401 - AARON ASKEW911750212 - DESERT BONE & JOINT SPECIALISTS, LLPOROrthopaedic Trauma Physician (207XX0801X)
United
88280$33.471538522412 - TENET HOSPITALS LIMITED, THE HOSPITALS OF PROVIDENCE TRANSMOUNTAIN CAMPUS954537720TXGeneral Acute Care Hospital (282N00000X)
United
88280$42.291235122029 - BAYCARE HOME CARE, INC.593582520 - (FL) BAYCARE HOME CARE INCFLHome Health Agency (251E00000X)
United
88280$13.771255478004 - CHRISTOPHER RAIO113438973 - ST JOSEPH HOSPITALNYEmergency Medicine Physician (207P00000X)
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist

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CPT 88280 vs. Other Pathology and Laboratory Procedures Codes

The CPT 88280 code is part of the Cytogenetic Studies services used for Pathology and Laboratory Procedures. It represents a moderate-complexity encounter and is one of several codes that vary based on time spent, level of medical decision-making, and documentation requirements.

The CPT 88280 code involves more provider time and moderate medical decision-making, unlike lower-level codes that require less time and simpler assessments. It typically includes multiple diagnoses, medication management, or test interpretation, leading to higher reimbursement and more detailed documentation requirements.

CodeComplexityDescription
88272-CPTLowChromosome Genetic Study, The Test Uses A Fluorescent Stain To Detect Dna Sequence In Cells. Dna Sequence Determines An Individuals Genetic Makeup.
88273-CPTLowMolecular Cytogenetics Chromo, Molecular Cytogenetics Chromosomal In Situ Hybridizationanalyze 10-30 Cells (Eg For Microdeletions) Molecular Cytogenetics Chromosomal In Situ Hybridization
88274-CPTLowGenetic Analysis Of Cells, This Study Uses A Technique That Separates And Recombines A Dna Strand Directly On A Viewing Slide. The Technique Analyzes How A Genetic Alteration Affects The Number Of Genes In A Specified Number Of Cells.
88280-CPTLowAdditional Genetic Study, Additional Studies Of Full Chromosome Sets That Describes A Persons Genetic Makeup (Karyotypes) Beyond The Base Chromosome Analysis. Karyotypes Help To Identify And Organize Genetic Abnormalities And Can Pinpoint Diagnosis Of Certain Cancers.

What is a fee schedule?

A fee schedule is a list of fixed prices that healthcare providers charge for specific services, including CPT 88280. These prices vary depending on payer type (Medicare, Medicaid, private insurance), geographic location, and provider contracts.

Understanding the 88280 fee schedule helps patients estimate costs and providers optimize billing for accurate reimbursements.

Factors that affect fee schedules


Medicare & Medicaid Rates

Government-set reimbursement amounts


Private Insurance Rates

Negotiated rates between providers and insurance companies


Geographic Location

Costs may be higher in urban areas.


Provider Type

Hospital providers may have different rates than private practice.

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