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CPT 88377 Fee Schedule

Last Verified: November 2025

Healthcare providers use this code to document and receive reimbursement for visits that address moderate-level medical decision-making, often including multiple diagnoses or prescription management.

Morphometric Analysis, In Situ Hybridization (Quantitative Or Semi-Quantitative), Manual, Per Specimen; Each Multiplex Probe Stain Procedure
Key FactDetail
Service Type

Pathology and Laboratory Procedures

Surgical Pathology Procedures

Common Place of Service

81 - Independent Laboratory

22 - On Campus Outpatient Hospital

Common Modifiers

None

26 - Professional component

TC - Technical component

Complexity LevelModerate
CMS$376.19 Physician Fee Schedule

National average reimbursement for CPT 88377 by major payers:

bcbs

$404.65

uhc

$286.27

aetna

$386.33

cigna

$392.11

Preview provider-level rates for...
For billing codeCPT 88377
PayerCodeRateNPITax IDStateSpecialty

Select a payer to view fee schedule data

Choose a payer from the options above to see rates for CPT 88377

United
88377$71.081841691136 - COLLEEN SHARMA593238640 - H LEE MOFFITT CANCER CTR & RES INST LIFE TIME CANCER SCRN CTR INCWIPhysician Assistant (363A00000X)
United
88377$346.391710375118 - SANDRA BRYANT593238640 - H LEE MOFFITT CANCER CTR & RES INST LIFE TIME CANCER SCRN CTR INCFLFamily Nurse Practitioner (363LF0000X)
United
88377$83.621679849582 - ANDREAS SALTOS593238640 - H LEE MOFFITT CANCER CTR & RES INST LIFE TIME CANCER SCRN CTR INCFLHematology & Oncology Physician (207RH0003X)
United
88377$407.511619938123 - RICHARD LEVINE593238640 - H LEE MOFFITT CANCER CTR & RES INST LIFE TIME CANCER SCRN CTR INCFLHematology & Oncology Physician (207RH0003X)
United
88377$71.081710375118 - SANDRA BRYANT593238640 - H LEE MOFFITT CANCER CTR & RES INST LIFE TIME CANCER SCRN CTR INCFLFamily Nurse Practitioner (363LF0000X)
United
88377$83.621598799413 - RAJ PASPULATI593238640 - H LEE MOFFITT CANCER CTR & RES INST LIFE TIME CANCER SCRN CTR INCFLDiagnostic Radiology Physician (2085R0202X)
United
88377$417.481528503661 - RACHELLE RODRIGUEZ593238640 - H LEE MOFFITT CANCER CTR & RES INST LIFE TIME CANCER SCRN CTR INCFLNurse Practitioner (363L00000X)
United
88377$417.481295732311 - JEAN AERTKER593238640 - H LEE MOFFITT CANCER CTR & RES INST LIFE TIME CANCER SCRN CTR INCFLOccupational Health Nurse Practitioner (363LX0106X)
United
88377$83.621134616337 - DAVID DETZ593238640 - H LEE MOFFITT CANCER CTR & RES INST LIFE TIME CANCER SCRN CTR INCFLSurgical Oncology Physician (2086X0206X)
United
88377$417.481710375118 - SANDRA BRYANT593238640 - H LEE MOFFITT CANCER CTR & RES INST LIFE TIME CANCER SCRN CTR INCFLFamily Nurse Practitioner (363LF0000X)
United
88377$346.391215467642 - ERIC SCHECK593238640 - H LEE MOFFITT CANCER CTR & RES INST LIFE TIME CANCER SCRN CTR INCFLPrimary Care Nurse Practitioner (363LP2300X)
United
88377$491.161982600284 - MARIA BRAZIL593238640 - H LEE MOFFITT CANCER CTR & RES INST LIFE TIME CANCER SCRN CTR INCMOAnesthesiology Physician (207L00000X)
United
88377$417.481154078103 - NIMMI MAXMILLIAN593238640 - H LEE MOFFITT CANCER CTR & RES INST LIFE TIME CANCER SCRN CTR INCFLFamily Nurse Practitioner (363LF0000X)
United
88377$491.161083815880 - ANDREW SERDIUK593238640 - H LEE MOFFITT CANCER CTR & RES INST LIFE TIME CANCER SCRN CTR INCFLAnesthesiology Physician (207L00000X)
United
88377$83.621023540184 - HOLLY O'BRIEN593238640 - H LEE MOFFITT CANCER CTR & RES INST LIFE TIME CANCER SCRN CTR INCFLInternal Medicine Physician (207R00000X)
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist

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CPT 88377 vs. Other Surgical Pathology Procedures Codes

The CPT 88377 code is part of the Pathology and Laboratory Procedures services used for Surgical Pathology Procedures. It represents a moderate-complexity encounter and is one of several codes that vary based on time spent, level of medical decision-making, and documentation requirements.

The CPT 88377 code involves more provider time and moderate medical decision-making, unlike lower-level codes that require less time and simpler assessments. It typically includes multiple diagnoses, medication management, or test interpretation, leading to higher reimbursement and more detailed documentation requirements.

CodeComplexityDescription
88371-CPTLowProt Anal Tiss West Blot Inter/Rept
88372-CPTLowProtein Analysis Of Tissue By Western Blot, With Interpretation And Report; Immunological Probe For Band Identification, Each
88373-CPTLowMorphometric Analysis In Situ Hybridization (Quantitative Or Semi-Quantitative) Using Computer-Assisted Technology Per Specimen; Each Additional Single Probe Stain Procedure (List Separately In Addition To Code For Primary Procedure)
88377-CPTModerateMorphometric Analysis, In Situ Hybridization (Quantitative Or Semi-Quantitative), Manual, Per Specimen; Each Multiplex Probe Stain Procedure

What is a fee schedule?

A fee schedule is a list of fixed prices that healthcare providers charge for specific services, including CPT 88377. These prices vary depending on payer type (Medicare, Medicaid, private insurance), geographic location, and provider contracts.

Understanding the 88377 fee schedule helps patients estimate costs and providers optimize billing for accurate reimbursements.

Factors that affect fee schedules


Medicare & Medicaid Rates

Government-set reimbursement amounts


Private Insurance Rates

Negotiated rates between providers and insurance companies


Geographic Location

Costs may be higher in urban areas.


Provider Type

Hospital providers may have different rates than private practice.

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