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See a sample rate comparisonCPT 96446 Fee Schedule
Last Verified: September 2026
Healthcare providers use this code to document and receive reimbursement for visits that address moderate-level medical decision-making, often including multiple diagnoses or prescription management.
Drug Instilled Into Body Space, A Chemotherapy Agent Or Other Complex Drug Is Given By Instilling One Or More Drugs Into A Body Cavity Or Space. The Drug May Be Injected Though A Thin Tube (Catheter) That Has Been Implanted Previously.
| Key Fact | Detail |
|---|---|
| Service Type | Medicine Services and Procedures Hydration, Therapeutic, Prophylactic, Diagnostic Injections and Infusions, and Chemotherapy and Other Highly Complex Drug or Highly Complex Biologic Agent Administration |
| Common Place of Service | 21 - Inpatient Hospital 11 - Office |
| Common Modifiers | None 59 - Distinct Procedural Service Q1 - Routine clinical service provided in a clinical research study |
| Complexity Level | Moderate |
| Medicare Fee Schedule | View Medicare rates for 96446 |
| Medicaid Fee Schedule | View Medicaid rates for 96446 |
National average reimbursement for CPT 96446 by major payers:
$236.87
$245.17
$253.06
$298.79
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CPT 96446
5 of 25 sample ratesHigher to lower in this preview
John Millichap
Pediatric Faculty Foundation In
$436.55Published rateHaidar Kabbani
$376.33Published rateGeorge Gianakakos
Loyola University Medical Center
$320.48Published rateKelley Volpe
The Board Of Trustees Of The University Of Illinois
$261.04Published rateMy Phon Nguyen
Mount Sinai Community Foundation
$31.93Published rate
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Payer Contract Negotiation
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See a sample payer proposalCPT 96446 vs. Other Hydration, Therapeutic, Prophylactic, Diagnostic Injections and Infusions, and Chemotherapy and Other Highly Complex Drug or Highly Complex Biologic Agent Administration Codes
The CPT 96446 code is part of the Medicine Services and Procedures services used for Hydration, Therapeutic, Prophylactic, Diagnostic Injections and Infusions, and Chemotherapy and Other Highly Complex Drug or Highly Complex Biologic Agent Administration. It represents a moderate-complexity encounter and is one of several codes that vary based on time spent, level of medical decision-making, and documentation requirements.
The CPT 96446 code involves more provider time and moderate medical decision-making, unlike lower-level codes that require less time and simpler assessments. It typically includes multiple diagnoses, medication management, or test interpretation, leading to higher reimbursement and more detailed documentation requirements.
| Code | Complexity | Description |
|---|---|---|
| 96425-CPT | Moderate | Chemotherapy Infusion Method, Chemotherapy Administration Intra Arterial Infusion Technique Initiation Of Prolonged Infusion More Than 8 Hours Requiring The Use Of A Portable Or Implantable Pump |
| 96440-CPT | Moderate | Drug Instilled Into Body Space, A Chemotherapy Agent Or Other Complex Drug Is Given By Instilling One Or More Drugs Into A Body Cavity Or Space. The Drug May Be Injected Though A Thin Tube (Catheter) That Has Been Implanted Previously. |
| 96446-CPT | Moderate | Drug Instilled Into Body Space, A Chemotherapy Agent Or Other Complex Drug Is Given By Instilling One Or More Drugs Into A Body Cavity Or Space. The Drug May Be Injected Though A Thin Tube (Catheter) That Has Been Implanted Previously. |
| 96521-CPT | Low | Infusion Pump Maintenance, Refill And Maintenance Of Either A Portable Or An Implanted Pump Used For Delivering Chemotherapy. |
What is a fee schedule?
A fee schedule is a list of fixed prices that healthcare providers charge for specific services, including CPT 96446. These prices vary depending on payer type (Medicare, Medicaid, private insurance), geographic location, and provider contracts.
Understanding the 96446 fee schedule helps patients estimate costs and providers optimize billing for accurate reimbursements.
Factors that affect fee schedules
Medicare & Medicaid Rates
Government-set reimbursement amounts
Private Insurance Rates
Negotiated rates between providers and insurance companies
Geographic Location
Costs may be higher in urban areas.
Provider Type
Hospital providers may have different rates than private practice.
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