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HCPCS A4221 Fee Schedule

Last Verified: January 2026

Healthcare providers use this code to document and receive reimbursement for visits that address moderate-level medical decision-making, often including multiple diagnoses or prescription management.

Supplies for maintenance of non-insulin drug infusion catheter, per week (list drugs separately)
Key FactDetail
Service Type

Medical And Surgical Supplies

Injection and Infusion Supplies

Complexity LevelLow

National average reimbursement for HCPCS A4221 by major payers:

bcbs

$21.24

uhc

$15.61

aetna

$18.35

cigna

$30.14

Preview provider-level rates for...
For billing codeHCPCS A4221
PayerCodeRateNPITax IDStateSpecialty

Select a payer to view fee schedule data

Choose a payer from the options above to see rates for HCPCS A4221

United
A4221$13.331023342532 - ABILENE KIDNEY CLINIC, P.A.270962460 - ABILENE KIDNEY CLINIC, P.A.TXNephrology Physician (207RN0300X)
United
A4221$10.961538737275 - DFW FAMILY CLINIC863692901 - DFW FAMILY CLINICTXFamily Medicine Physician (207Q00000X)
United
A4221$21.651477871184 - DAVID GREENBERG756002868TXInfectious Disease Physician (207RI0200X)
United
A4221$15.171790478444 - INTENSIVIST MEDICINE SERVICES OF TX, PC923083345 - INTENSIVIST MEDICINE SERVICES OF TX PCTXCritical Care Medicine (Internal Medicine) Physician (207RC0200X)
United
A4221$13.151336267871 - MADHURI SOPIRALA756002868TXInfectious Disease Physician (207RI0200X)
United
A4221$10.961902485618 - MIND-BODY HEALTH COACHING OF NORTH TEXAS853220670 - MINDBODY HEALTH COACHING OF NORTH TEXASTXMulti-Specialty Group (193200000X)
United
A4221$21.651295027910 - RAWN BOSLEY752286998 - DALLAS ASSOCIATED DERMATOLOGISTS, PLLCTXDermatology Physician (207N00000X)
United
A4221$21.651124250410 - CENTRAL TEXAS MEDICAL SPECIALISTS PLLC460829574 - CENTRAL TEXAS MEDICAL SPECIALISTS, PLLCTXMulti-Specialty Group (193200000X)
United
A4221$21.651245686609 - MEGAN TRAINOR10690116 - SUSAN E. DOZIER, M.D., P.A.TXDermatology Physician (207N00000X)
United
A4221$10.961922648310 - CEDAR CREEK WELLNESS GROUP844266300 - CEDAR CREEK WELLNESS GROUPTXPsychiatric/Mental Health Nurse Practitioner (363LP0808X)
United
A4221$11.831699943191 - HIGH COUNTRY COMMUNITY RURAL HEALTH CLINIC751702162TXMedical Physician Assistant (363AM0700X)
United
A4221$21.651508052036 - DONALD GLASS756002868TXDermatology Physician (207N00000X)
United
A4221$13.151437437860 - ABBY LAU756002868TXInfectious Disease Physician (207RI0200X)
United
A4221$22.031134652993 - FRANK WINSETT760010407TXSingle Specialty Group (193400000X)
United
A4221$10.961861426934 - M & M NORTH, LLP20776970 - M M NORTH LLPTXFamily Medicine Physician (207Q00000X)
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist

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HCPCS A4221 vs. Other Injection and Infusion Supplies Codes

The HCPCS A4221 code is part of the Medical And Surgical Supplies services used for Injection and Infusion Supplies. It represents a moderate-complexity encounter and is one of several codes that vary based on time spent, level of medical decision-making, and documentation requirements.

The HCPCS A4221 code involves more provider time and moderate medical decision-making, unlike lower-level codes that require less time and simpler assessments. It typically includes multiple diagnoses, medication management, or test interpretation, leading to higher reimbursement and more detailed documentation requirements.

CodeComplexityDescription
A4220-HCPCSLowRefill kit for implantable infusion pump
A4221-HCPCSLowSupplies for maintenance of non-insulin drug infusion catheter, per week (list drugs separately)
A4222-HCPCSLowInfusion supplies for external drug infusion pump, per cassette or bag (list drugs separately)

What is a fee schedule?

A fee schedule is a list of fixed prices that healthcare providers charge for specific services, including HCPCS A4221. These prices vary depending on payer type (Medicare, Medicaid, private insurance), geographic location, and provider contracts.

Understanding the A4221 fee schedule helps patients estimate costs and providers optimize billing for accurate reimbursements.

Factors that affect fee schedules


Medicare & Medicaid Rates

Government-set reimbursement amounts


Private Insurance Rates

Negotiated rates between providers and insurance companies


Geographic Location

Costs may be higher in urban areas.


Provider Type

Hospital providers may have different rates than private practice.

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