HCPCS J0221 (Lumizyme) Fee Schedule
Healthcare providers use this code to document and receive reimbursement for visits that address moderate-level medical decision-making, often including multiple diagnoses or prescription management.
| Key Fact | Detail |
|---|---|
| Service Type | • Drugs Administered Other than Oral Method • Drugs, Administered by Injection |
| Common Place of Service | • None • 99 - Other POS |
| Complexity Level | Moderate |
| Medicare Payment Limit | |
| WAC Price | Lorem ipsum dolor sit amet consectetur Lorem ipsum dolor sit amet consectetur VisitBuyandBill.com |
National average reimbursement for HCPCS J0221 by major payers:

$218.98

$206.61

$218.04

$214.16
| Payer | Code | Rate | NPI | Tax ID | State | Specialty |
|---|---|---|---|---|---|---|
Select a payer to view fee schedule data Choose a payer from the options above to see rates for HCPCS J0221 | ||||||
United | J0221 | $213.74 | 1306245626 - MENG QIAN | 135562308 - NEW YORK UNIVERSITY | NY | General Acute Care Hospital (282N00000X) |
United | J0221 | $201.63 | 1558637017 - ST. JOSEPH REGIONAL MEDICAL CENTER, ST. JOSEPH MEDICAL GROUP | 364851166 | ID | General Acute Care Hospital (282N00000X) |
United | J0221 | $173.64 | 1912303579 - PRIME HEALTHCARE SERVICES BLUE SPRINGS, LLC, ST. MARY'S MEDICAL CENTER | 472264005 | MO | General Acute Care Hospital (282N00000X) |
United | J0221 | $166.49 | 1538208210 - RIVERSIDE MEDICAL CENTER | 362414944 - (IL) RIVERSIDE MEDICAL CENTER | IL | General Acute Care Hospital (282N00000X) |
United | J0221 | $181.77 | 1932123569 - JOHNSON MEMORIAL HOSPITAL, INC. | 60646696 - (CT) JOHNSON MEMORIAL HOSPITAL | CT | General Acute Care Hospital (282N00000X) |
United | J0221 | $366.13 | 1699752915 - FAIRVIEW HEALTH SERVICES, FAIRVIEW SOUTHDALE HOSPITAL | 410991680 - FAIRVIEW HEALTH SERVICES | MN | General Acute Care Hospital (282N00000X) |
United | J0221 | $201.63 | 1962758375 - OSS ORTHOPAEDIC HOSPITAL, LLC, OSS HEALTH | 800458999 - (PA) OSS HEALTH | PA | General Acute Care Hospital (282N00000X) |
United | J0221 | $234.35 | 1316137201 - MEDSTAR GEORGETOWN MEDICAL CENTER, INC, GEORGETOWN UNIVERSITY HOSPITAL PHYSICIANS | 522218584 - (DC) MEDSTAR-GEORGETOWN MEDICAL CENTER INC | DC | General Acute Care Hospital (282N00000X) |
United | J0221 | $201.66 | 1780667923 - SOUTH BROWARD HOSPITAL DISTRICT, MEMORIAL REGIONAL HOSPITAL | 596014973 - (FL) SOUTH BROWARD HOSPITAL DISTRICT | FL | General Acute Care Hospital (282N00000X) |
United | J0221 | $166.49 | 1710683354 - MEDICAL UNIVERSITY HOSPITAL AUTHORITY | 571098556 - (SC) MEDICAL UNIVERSITY HOSPITAL AUTHORITY | SC | General Acute Care Hospital (282N00000X) |
United | J0221 | $201.63 | 1144590522 - ST. VINCENT INFIRMARY MEDICAL CENTER, ST. VINCENT HEART CLINIC ARKANSAS | 710236917 - (AR) ST VINCENT INFIRMARY MEDICAL CENTER | AR | General Acute Care Hospital (282N00000X) |
United | J0221 | $201.97 | 1043265564 - MONROE HMA, LLC, CLEARVIEW REGIONAL MEDICAL CENTER | 200141568 - (GA) MONROE HMA LLC | GA | General Acute Care Hospital (282N00000X) |
United | J0221 | $201.97 | 1255372397 - GREATER BALTIMORE MEDICAL CENTER, INC. | 521411931 - (MD) GREATER BALTIMORE MEDICAL CENTER INC | MD | General Acute Care Hospital (282N00000X) |
United | J0221 | $201.97 | 1013074061 - PUBLIC HOSPITAL DISTRICT 1 OF SNOHOMISH COUNTY, EVERGREENHEALTH MONROE | 916018764 | WA | General Acute Care Hospital (282N00000X) |
United | J0221 | $201.63 | 1699235374 - AHN EMERUS WESTMORELAND LLC, AHN HEMPFIELD NEIGHBORHOOD HOSPITAL | 823697883 - (PA) AHN EMERUS WESTMORELAND LLC | PA | General Acute Care Hospital (282N00000X) |
United | 99202 | $100.00 | 1234567890 | 1234567890 | CA | Cardiologist |
United | 99202 | $100.00 | 1234567890 | 1234567890 | CA | Cardiologist |
United | 99202 | $100.00 | 1234567890 | 1234567890 | CA | Cardiologist |
United | 99202 | $100.00 | 1234567890 | 1234567890 | CA | Cardiologist |
United | 99202 | $100.00 | 1234567890 | 1234567890 | CA | Cardiologist |
United | 99202 | $100.00 | 1234567890 | 1234567890 | CA | Cardiologist |
United | 99202 | $100.00 | 1234567890 | 1234567890 | CA | Cardiologist |
United | 99202 | $100.00 | 1234567890 | 1234567890 | CA | Cardiologist |
United | 99202 | $100.00 | 1234567890 | 1234567890 | CA | Cardiologist |
United | 99202 | $100.00 | 1234567890 | 1234567890 | CA | Cardiologist |
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HCPCS J0221 vs. Other Drugs, Administered by Injection Codes
The HCPCS J0221 code is part of the Drugs Administered Other than Oral Method services used for Drugs, Administered by Injection. It represents a moderate-complexity encounter and is one of several codes that vary based on time spent, level of medical decision-making, and documentation requirements.
The HCPCS J0221 code involves more provider time and moderate medical decision-making, unlike lower-level codes that require less time and simpler assessments. It typically includes multiple diagnoses, medication management, or test interpretation, leading to higher reimbursement and more detailed documentation requirements.
| Code | Complexity | Description |
|---|---|---|
| J0220-HCPCS | Low | Injection, alglucosidase alfa, 10 mg, not otherwise specified |
| J0221-HCPCS | Moderate | Injection, alglucosidase alfa, (Lumizyme), 10 mg |
| J0222-HCPCS | Low | Injection, Patisiran, 0.1 mg |
What is a fee schedule?
A fee schedule is a list of fixed prices that healthcare providers charge for specific services, including HCPCS J0221. These prices vary depending on payer type (Medicare, Medicaid, private insurance), geographic location, and provider contracts.
Understanding the J0221 fee schedule helps patients estimate costs and providers optimize billing for accurate reimbursements.
Factors that affect fee schedules
Medicare & Medicaid Rates
Government-set reimbursement amounts
Private Insurance Rates
Negotiated rates between providers and insurance companies
Geographic Location
Costs may be higher in urban areas.
Provider Type
Hospital providers may have different rates than private practice.
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