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HCPCS J0221 (Lumizyme) Fee Schedule

Last Verified: January 2026

Healthcare providers use this code to document and receive reimbursement for visits that address moderate-level medical decision-making, often including multiple diagnoses or prescription management.

Injection, alglucosidase alfa, (Lumizyme), 10 mg
Key FactDetail
Service Type

Drugs Administered Other than Oral Method

Drugs, Administered by Injection

Common Place of Service

None

99 - Other POS

Complexity LevelModerate
Medicare Payment Limit
$206.589BuyandBill.com
WAC Price
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National average reimbursement for HCPCS J0221 by major payers:

bcbs

$218.98

uhc

$206.61

aetna

$218.04

cigna

$214.16

Preview provider-level rates for...
For billing codeHCPCS J0221
PayerCodeRateNPITax IDStateSpecialty

Select a payer to view fee schedule data

Choose a payer from the options above to see rates for HCPCS J0221

United
J0221$213.741306245626 - MENG QIAN135562308 - NEW YORK UNIVERSITYNYGeneral Acute Care Hospital (282N00000X)
United
J0221$201.631558637017 - ST. JOSEPH REGIONAL MEDICAL CENTER, ST. JOSEPH MEDICAL GROUP364851166IDGeneral Acute Care Hospital (282N00000X)
United
J0221$173.641912303579 - PRIME HEALTHCARE SERVICES BLUE SPRINGS, LLC, ST. MARY'S MEDICAL CENTER472264005MOGeneral Acute Care Hospital (282N00000X)
United
J0221$166.491538208210 - RIVERSIDE MEDICAL CENTER362414944 - (IL) RIVERSIDE MEDICAL CENTERILGeneral Acute Care Hospital (282N00000X)
United
J0221$181.771932123569 - JOHNSON MEMORIAL HOSPITAL, INC.60646696 - (CT) JOHNSON MEMORIAL HOSPITALCTGeneral Acute Care Hospital (282N00000X)
United
J0221$366.131699752915 - FAIRVIEW HEALTH SERVICES, FAIRVIEW SOUTHDALE HOSPITAL410991680 - FAIRVIEW HEALTH SERVICESMNGeneral Acute Care Hospital (282N00000X)
United
J0221$201.631962758375 - OSS ORTHOPAEDIC HOSPITAL, LLC, OSS HEALTH800458999 - (PA) OSS HEALTHPAGeneral Acute Care Hospital (282N00000X)
United
J0221$234.351316137201 - MEDSTAR GEORGETOWN MEDICAL CENTER, INC, GEORGETOWN UNIVERSITY HOSPITAL PHYSICIANS522218584 - (DC) MEDSTAR-GEORGETOWN MEDICAL CENTER INCDCGeneral Acute Care Hospital (282N00000X)
United
J0221$201.661780667923 - SOUTH BROWARD HOSPITAL DISTRICT, MEMORIAL REGIONAL HOSPITAL596014973 - (FL) SOUTH BROWARD HOSPITAL DISTRICTFLGeneral Acute Care Hospital (282N00000X)
United
J0221$166.491710683354 - MEDICAL UNIVERSITY HOSPITAL AUTHORITY571098556 - (SC) MEDICAL UNIVERSITY HOSPITAL AUTHORITYSCGeneral Acute Care Hospital (282N00000X)
United
J0221$201.631144590522 - ST. VINCENT INFIRMARY MEDICAL CENTER, ST. VINCENT HEART CLINIC ARKANSAS710236917 - (AR) ST VINCENT INFIRMARY MEDICAL CENTERARGeneral Acute Care Hospital (282N00000X)
United
J0221$201.971043265564 - MONROE HMA, LLC, CLEARVIEW REGIONAL MEDICAL CENTER200141568 - (GA) MONROE HMA LLCGAGeneral Acute Care Hospital (282N00000X)
United
J0221$201.971255372397 - GREATER BALTIMORE MEDICAL CENTER, INC.521411931 - (MD) GREATER BALTIMORE MEDICAL CENTER INCMDGeneral Acute Care Hospital (282N00000X)
United
J0221$201.971013074061 - PUBLIC HOSPITAL DISTRICT 1 OF SNOHOMISH COUNTY, EVERGREENHEALTH MONROE916018764WAGeneral Acute Care Hospital (282N00000X)
United
J0221$201.631699235374 - AHN EMERUS WESTMORELAND LLC, AHN HEMPFIELD NEIGHBORHOOD HOSPITAL823697883 - (PA) AHN EMERUS WESTMORELAND LLCPAGeneral Acute Care Hospital (282N00000X)
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist

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HCPCS J0221 vs. Other Drugs, Administered by Injection Codes

The HCPCS J0221 code is part of the Drugs Administered Other than Oral Method services used for Drugs, Administered by Injection. It represents a moderate-complexity encounter and is one of several codes that vary based on time spent, level of medical decision-making, and documentation requirements.

The HCPCS J0221 code involves more provider time and moderate medical decision-making, unlike lower-level codes that require less time and simpler assessments. It typically includes multiple diagnoses, medication management, or test interpretation, leading to higher reimbursement and more detailed documentation requirements.

CodeComplexityDescription
J0220-HCPCSLowInjection, alglucosidase alfa, 10 mg, not otherwise specified
J0221-HCPCSModerateInjection, alglucosidase alfa, (Lumizyme), 10 mg
J0222-HCPCSLowInjection, Patisiran, 0.1 mg

What is a fee schedule?

A fee schedule is a list of fixed prices that healthcare providers charge for specific services, including HCPCS J0221. These prices vary depending on payer type (Medicare, Medicaid, private insurance), geographic location, and provider contracts.

Understanding the J0221 fee schedule helps patients estimate costs and providers optimize billing for accurate reimbursements.

Factors that affect fee schedules


Medicare & Medicaid Rates

Government-set reimbursement amounts


Private Insurance Rates

Negotiated rates between providers and insurance companies


Geographic Location

Costs may be higher in urban areas.


Provider Type

Hospital providers may have different rates than private practice.

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