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HCPCS J0491 (Saphnelo) Fee Schedule

Last Verified: November 2025

Healthcare providers use this code to document and receive reimbursement for visits that address moderate-level medical decision-making, often including multiple diagnoses or prescription management.

Injection, anifrolumab-fnia, 1 mg
Key FactDetail
Service Type

Drugs Administered Other than Oral Method

Drugs, Administered by Injection

Common Place of Service

11 - Office

None

Complexity LevelLow
Medicare Payment Limit
$18.079BuyandBill.com
WAC Price
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Related NDC Codes

00310-3040-00 - SAPHNELO (PF) 150 MG/1 ML


National average reimbursement for HCPCS J0491 by major payers:

bcbs

$19.15

uhc

$17.70

aetna

$18.90

cigna

$18.30

Preview provider-level rates for...
For billing codeHCPCS J0491
PayerCodeRateNPITax IDStateSpecialty

Select a payer to view fee schedule data

Choose a payer from the options above to see rates for HCPCS J0491

United
J0491$17.291770809535 - EDGARDO COLON-PINEIRO842099145 - (TX) E J FAMILY HEALTH CENTER PLLCTXFamily Medicine Physician (207Q00000X)
United
J0491$17.181225472418 - ALLIE LOHRMEYER486023060 - (KS) CLAY COUNTY MEDICAL CENTERKSFamily Medicine Physician (207Q00000X)
United
J0491$17.291942212527 - BANITA SEHGAL471421985 - (TX) WELLSPRING PHYSICIAN PACAInternal Medicine Physician (207R00000X)
United
J0491$17.181114927118 - SUSAN ANDERSON752661960 - (TX) PCA-PRIMARY CARE ASSOCIATES, P.A.TXFamily Medicine Physician (207Q00000X)
United
J0491$17.321447736665 - ARTEM AESTHESTICS & WELLNESS LLC824678946 - (AZ) ARTEM AESTHESTICS WELLNESS LLCAZInternal Medicine Physician (207R00000X)
United
J0491$17.291790951481 - MICHAEL D MARLOW, D.O., P.A., MARLOW FAMILY CARE510448127 - (TX) MICHAEL D. MARLOW DO, PATXFamily Medicine Physician (207Q00000X)
United
J0491$17.181114031507 - STEVEN BOLES200663620 - (AZ) STEVEN C BOLES DO PLCAZFamily Medicine Physician (207Q00000X)
United
J0491$33.271689053183 - ANDREW HAWRYLAK742958277 - SCOTT & WHITE CLINICTXInternal Medicine Physician (207R00000X)
United
J0491$47.751427094770 - DIVESH ANIREDDY261607348 - (AK) MATSU VALLEY III LLCAZGastroenterology Physician (207RG0100X)
United
J0491$30.371588008890 - ALAN NAIM200358722 - (CA) UNITED MEDICAL DOCTORSAZGastroenterology Physician (207RG0100X)
United
J0491$33.271730370925 - SAMEERA VOHRA742958277 - SCOTT & WHITE CLINICTXInternal Medicine Physician (207R00000X)
United
J0491$17.131336868611 - VP HEALTH & CO LLC, VP HEALTH & CO882885024 - (TX) VP HEALTH CO LLCTXFamily Medicine Physician (207Q00000X)
United
J0491$17.291831385673 - FAMILY MEDICAL GROUP NORTHEAST, P.C.273674492 - OREGON HEALTHCARE RESOURCES, LLCORFamily Medicine Physician (207Q00000X)
United
J0491$17.291548661713 - GERINATION MEDICAL CENTERS, LLC471769255 - (TX) GERINATION MEDICAL CENTERS LLCTXFamily Medicine Physician (207Q00000X)
United
J0491$17.291801045182 - HANSFORD COUNTY HOSPITAL DISTRICT, PALO DURO HEALTH CENTER237297190 - (TX) HANSFORD COUNTY HOSPITAL DISTRICTTXFamily Medicine Physician (207Q00000X)
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist

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HCPCS J0491 vs. Other Drugs, Administered by Injection Codes

The HCPCS J0491 code is part of the Drugs Administered Other than Oral Method services used for Drugs, Administered by Injection. It represents a moderate-complexity encounter and is one of several codes that vary based on time spent, level of medical decision-making, and documentation requirements.

The HCPCS J0491 code involves more provider time and moderate medical decision-making, unlike lower-level codes that require less time and simpler assessments. It typically includes multiple diagnoses, medication management, or test interpretation, leading to higher reimbursement and more detailed documentation requirements.

CodeComplexityDescription
00310-3040-00-NDCModerateSAPHNELO (PF) 150 MG/1 ML
J0490-HCPCSLowInjection, belimumab, 10 mg
J0491-HCPCSLowInjection, anifrolumab-fnia, 1 mg
J0500-HCPCSLowInjection, dicyclomine HCl, up to 20 mg

What is a fee schedule?

A fee schedule is a list of fixed prices that healthcare providers charge for specific services, including HCPCS J0491. These prices vary depending on payer type (Medicare, Medicaid, private insurance), geographic location, and provider contracts.

Understanding the J0491 fee schedule helps patients estimate costs and providers optimize billing for accurate reimbursements.

Factors that affect fee schedules


Medicare & Medicaid Rates

Government-set reimbursement amounts


Private Insurance Rates

Negotiated rates between providers and insurance companies


Geographic Location

Costs may be higher in urban areas.


Provider Type

Hospital providers may have different rates than private practice.

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