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HCPCS Q4281 Fee Schedule

Last Verified: December 2025

Healthcare providers use this code to document and receive reimbursement for visits that address moderate-level medical decision-making, often including multiple diagnoses or prescription management.

Barrera sl or barrera dl, per square centimeter
Key FactDetail
Service Type

Temporary Codes

Skin Substitutes and Biologicals

Complexity LevelModerate
CMS$544.05 Drug ASP

National average reimbursement for HCPCS Q4281 by major payers:

bcbs

$417.03

uhc

$968.32

aetna

$882.43

cigna

$894.25

Preview provider-level rates for...
For billing codeHCPCS Q4281
PayerCodeRateNPITax IDStateSpecialty

Select a payer to view fee schedule data

Choose a payer from the options above to see rates for HCPCS Q4281

United
Q4281$2433.871700441920 - ARAME MOTAZEDI870737748CAFamily Medicine Physician (207Q00000X)
United
Q4281$2433.871831109974 - KATHLEEN TORRES870737748CAInternal Medicine Physician (207R00000X)
United
Q4281$1110.141730150848 - SUNIL PATEL943322757 - (CA) SUNIL H. PATEL, M.D. SOLE PROPRIETORSHIPCAInternal Medicine Physician (207R00000X)
United
Q4281$888.101194751289 - PATRICK GONZALES912105475 - (CA) PATRICK EDIVINA GONZALES MEDICAL GROUP INCCAInternal Medicine Physician (207R00000X)
United
Q4281$2385.191962426510 - JEFFREY BELANOFF870737748CAInternal Medicine Physician (207R00000X)
United
Q4281$888.101861834178 - IVAN BRANDO AGUILERA1861834178 - (CA) IVAN BRANDO AGUILERACAFoot & Ankle Surgery Podiatrist (213ES0103X)
United
Q4281$2385.191831109974 - KATHLEEN TORRES870737748CAInternal Medicine Physician (207R00000X)
United
Q4281$888.101144956954 - SHANT TOMASSIAN MD INC882090172 - (CA) SHANT TOMASSIAN MD INCCAFamily Medicine Physician (207Q00000X)
United
Q4281$2433.871205934593 - MARY GIMNESS870737748CAInternal Medicine Physician (207R00000X)
United
Q4281$2385.191205934593 - MARY GIMNESS870737748CAInternal Medicine Physician (207R00000X)
United
Q4281$888.101386670479 - EDIVINA GONZALES912105475 - (CA) PATRICK EDIVINA GONZALES MEDICAL GROUP INCCAInternal Medicine Physician (207R00000X)
United
Q4281$2433.871881705192 - YAROSLAV POGORELOV870737748CAFamily Medicine Physician (207Q00000X)
United
Q4281$888.101619905080 - PATRICK & EDIVINA GONZALES MEDICAL GROUP INC912105475 - (CA) PATRICK EDIVINA GONZALES MEDICAL GROUP INCCAInternal Medicine Physician (207R00000X)
United
Q4281$888.101710073697 - JUDITH ROMERO920578742 - (CA) ROMERO ADVANCED DERMATOLOGY INCCADermatology Physician (207N00000X)
United
Q4281$2385.191124686415 - HALEY MORTON870737748CAFamily Medicine Physician (207Q00000X)
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist

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HCPCS Q4281 vs. Other Skin Substitutes and Biologicals Codes

The HCPCS Q4281 code is part of the Temporary Codes services used for Skin Substitutes and Biologicals. It represents a moderate-complexity encounter and is one of several codes that vary based on time spent, level of medical decision-making, and documentation requirements.

The HCPCS Q4281 code involves more provider time and moderate medical decision-making, unlike lower-level codes that require less time and simpler assessments. It typically includes multiple diagnoses, medication management, or test interpretation, leading to higher reimbursement and more detailed documentation requirements.

CodeComplexityDescription
Q4280-HCPCSHighXcell amnio matrix, per square centimeter
Q4281-HCPCSModerateBarrera sl or barrera dl, per square centimeter
Q4282-HCPCSModerateCygnus dual, per square centimeter

What is a fee schedule?

A fee schedule is a list of fixed prices that healthcare providers charge for specific services, including HCPCS Q4281. These prices vary depending on payer type (Medicare, Medicaid, private insurance), geographic location, and provider contracts.

Understanding the Q4281 fee schedule helps patients estimate costs and providers optimize billing for accurate reimbursements.

Factors that affect fee schedules


Medicare & Medicaid Rates

Government-set reimbursement amounts


Private Insurance Rates

Negotiated rates between providers and insurance companies


Geographic Location

Costs may be higher in urban areas.


Provider Type

Hospital providers may have different rates than private practice.

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