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CPT 81255 Fee Schedule

Last Verified: November 2025

Healthcare providers use this code to document and receive reimbursement for visits that address moderate-level medical decision-making, often including multiple diagnoses or prescription management.

Hexa (Hexosaminidase A [Alpha Polypeptide]) (Eg, Tay-Sachs Disease) Gene Analysis, Common Variants (Eg, 1278instatc, 1421+1g>C, G269s)
Key FactDetail
Service Type

Pathology and Laboratory Procedures

Molecular Pathology Procedures

Common Place of Service

81 - Independent Laboratory

11 - Office

Common Modifiers

None

59 - Distinct Procedural Service

90 - Reference Laboratory

Complexity LevelLow

National average reimbursement for CPT 81255 by major payers:

bcbs

$47.64

uhc

$31.53

aetna

$67.54

cigna

$107.76

Preview provider-level rates for...
For billing codeCPT 81255
PayerCodeRateNPITax IDStateSpecialty

Select a payer to view fee schedule data

Choose a payer from the options above to see rates for CPT 81255

United
81255$21.611952424079 - CATHERINE KARIMOV272273686CAClinical Genetics (M.D.) Physician (207SG0201X)
United
81255$64.301588744908 - ALEKSANDAR RAJKOVIC943281657CAClinical Genetics (M.D.) Physician (207SG0201X)
United
81255$282.331851911705 - LAUREL HOCHSTETLER943281662CAGenetic Counselor (M.S.) (170300000X)
United
81255$51.451588744908 - ALEKSANDAR RAJKOVIC943281657CAClinical Genetics (M.D.) Physician (207SG0201X)
United
81255$83.431326643511 - HAYLEY WRIGHT260089066CAGenetic Counselor (M.S.) (170300000X)
United
81255$254.101780818302 - NIKKI MADSON943281666CAGenetic Counselor (M.S.) (170300000X)
United
81255$282.331851911705 - LAUREL HOCHSTETLER943281662CAGenetic Counselor (M.S.) (170300000X)
United
81255$21.611811932940 - TOURAN ZADEH330217468 - (CA) GENETICS CENTERCAClinical Genetics (M.D.) Physician (207SG0201X)
United
81255$254.101194701250 - VINAYA MURTHY943281660CAGenetic Counselor (M.S.) (170300000X)
United
81255$254.101588744908 - ALEKSANDAR RAJKOVIC943281657CAClinical Genetics (M.D.) Physician (207SG0201X)
United
81255$254.101093975435 - ALLYSON SCOTT943281660CAGenetic Counselor (M.S.) (170300000X)
United
81255$203.191427046325 - REGENTS OF THE UNIV OF CA, REGENTS/UCD PBG/ GENETICS330655905CAGenetics Clinic/Center (261QG0250X)
United
81255$51.451780818302 - NIKKI MADSON943281666CAGenetic Counselor (M.S.) (170300000X)
United
81255$149.941750834677 - MONICA STAMP475502470 - (CA) REGENTS OF THE UNIVERSITY OF CALIFORNIACAGenetic Counselor (M.S.) (170300000X)
United
81255$30.871669811022 - ANNA VILLA341369963 - (OH) BLANCHARD VALLEY REGIONAL HEALTH CENTERCAGenetic Counselor (M.S.) (170300000X)
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist

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CPT 81255 vs. Other Molecular Pathology Procedures Codes

The CPT 81255 code is part of the Pathology and Laboratory Procedures services used for Molecular Pathology Procedures. It represents a moderate-complexity encounter and is one of several codes that vary based on time spent, level of medical decision-making, and documentation requirements.

The CPT 81255 code involves more provider time and moderate medical decision-making, unlike lower-level codes that require less time and simpler assessments. It typically includes multiple diagnoses, medication management, or test interpretation, leading to higher reimbursement and more detailed documentation requirements.

CodeComplexityDescription
81251-CPTLowGba (Glucosidase, Beta, Acid) (Eg, Gaucher Disease) Gene Analysis, Common Variants (Eg, N370s, 84gg, L444p, Ivs2+1g>A)
81252-CPTLowGjb2 (Gap Junction Protein Beta 2 26kda; Connexin 26) (Eg. Nonsyndromic Hearing Loss) Gene Analysis; Full Gene Sequence
81253-CPTLowGjb2 (Gap Junction Protein, Beta 2, 26kda, Connexin 26) (Eg, Nonsyndromic Hearing Loss) Gene Analysis; Known Familial Variants
81255-CPTLowHexa (Hexosaminidase A [Alpha Polypeptide]) (Eg, Tay-Sachs Disease) Gene Analysis, Common Variants (Eg, 1278instatc, 1421+1g>C, G269s)

What is a fee schedule?

A fee schedule is a list of fixed prices that healthcare providers charge for specific services, including CPT 81255. These prices vary depending on payer type (Medicare, Medicaid, private insurance), geographic location, and provider contracts.

Understanding the 81255 fee schedule helps patients estimate costs and providers optimize billing for accurate reimbursements.

Factors that affect fee schedules


Medicare & Medicaid Rates

Government-set reimbursement amounts


Private Insurance Rates

Negotiated rates between providers and insurance companies


Geographic Location

Costs may be higher in urban areas.


Provider Type

Hospital providers may have different rates than private practice.

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