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CPT 81257 Fee Schedule

Last Verified: January 2026

Healthcare providers use this code to document and receive reimbursement for visits that address moderate-level medical decision-making, often including multiple diagnoses or prescription management.

Hba/Hba2 (Alpha Globin 1 And Alpha Globin 2) (Eg Alpha Thalassemia Hb Bart Hydrops Fetalis Syn- Drome Hbh Disease) Gene Analysis Common Deletions Or Variant (Eg Southeast Asian Thai Filipino Mediterranean Alpha3.7 Alpha4.2 Alpha20.5 And Constant Spring) (Desc Revised 1/1/2018)
Key FactDetail
Service Type

Pathology and Laboratory Procedures

Molecular Pathology Procedures

Common Place of Service

81 - Independent Laboratory

11 - Office

Common Modifiers

None

59 - Distinct Procedural Service

XU - Unusual Non-Overlapping Service

Complexity LevelLow
Medicare Fee ScheduleView Medicare rates for 81257

National average reimbursement for CPT 81257 by major payers:

bcbs

$88.59

uhc

$62.69

aetna

$106.97

cigna

$182.37

Preview provider-level rates for...
For billing codeCPT 81257
PayerCodeRateNPITax IDStateSpecialty

Select a payer to view fee schedule data

Choose a payer from the options above to see rates for CPT 81257

United
81257$92.021740910330 - BRENDEN PHUNG621647259 - TENNESSEE ONCOLOGY PLLCCAGenetic Counselor (M.S.) (170300000X)
United
81257$505.041083692354 - AMIE BLANCO943281662CAGenetic Counselor (M.S.) (170300000X)
United
81257$298.011750834677 - MONICA STAMP475502470 - (CA) REGENTS OF THE UNIVERSITY OF CALIFORNIACAGenetic Counselor (M.S.) (170300000X)
United
81257$561.151609352533 - ATHENA ANGELOPOULOS943281662CAGenetic Counselor (M.S.) (170300000X)
United
81257$42.951942683552 - CAITLIN HALE113650756 - (OR) MARC E. LEWIS, MD, LLCCAGenetic Counselor (M.S.) (170300000X)
United
81257$416.891609226992 - DANIELLA KAMARA954377219CAClinical Genetics (M.D.) Physician (207SG0201X)
United
81257$42.951952424079 - CATHERINE KARIMOV272273686CAClinical Genetics (M.D.) Physician (207SG0201X)
United
81257$296.791871970541 - WAI PARK274803222 - CITY OF HOPE MEDICAL FOUNDATIONCAClinical Genetics (M.D.) Physician (207SG0201X)
United
81257$127.831215121132 - OPHIR KLEIN943281657CAClinical Genetics (M.D.) Physician (207SG0201X)
United
81257$42.951295736734 - CHRISTUS HEALTH ARK-LA-TEX, CHRISTUS ST. MICHAEL HEALTH SYSTEM752749681 - (TX) CHRISTUS HEALTH ARKLATEXTXGeneral Acute Care Hospital (282N00000X)
United
81257$505.041609352533 - ATHENA ANGELOPOULOS943281662CAGenetic Counselor (M.S.) (170300000X)
United
81257$45.291396014866 - KATHRYN SINGH271504911 - (CA) MEMORIALCARE MEDICAL FOUNDATIONCAGenetic Counselor (M.S.) (170300000X)
United
81257$346.071184736225 - STACY GRAY274803222 - CITY OF HOPE MEDICAL FOUNDATIONCAClinical Genetics (M.D.) Physician (207SG0201X)
United
81257$561.151194701250 - VINAYA MURTHY943281657CAGenetic Counselor (M.S.) (170300000X)
United
81257$165.831447944269 - CASEY SCHERER260089066CAGenetic Counselor (M.S.) (170300000X)
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist

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CPT 81257 vs. Other Molecular Pathology Procedures Codes

The CPT 81257 code is part of the Pathology and Laboratory Procedures services used for Molecular Pathology Procedures. It represents a moderate-complexity encounter and is one of several codes that vary based on time spent, level of medical decision-making, and documentation requirements.

The CPT 81257 code involves more provider time and moderate medical decision-making, unlike lower-level codes that require less time and simpler assessments. It typically includes multiple diagnoses, medication management, or test interpretation, leading to higher reimbursement and more detailed documentation requirements.

CodeComplexityDescription
81251-CPTLowGba (Glucosidase, Beta, Acid) (Eg, Gaucher Disease) Gene Analysis, Common Variants (Eg, N370s, 84gg, L444p, Ivs2+1g>A)
81256-CPTLowHfe (Hemochromatosis) (Eg, Hereditary Hemochromatosis) Gene Analysis, Common Variants (Eg, C282y, H63d)
81257-CPTLowHba/Hba2 (Alpha Globin 1 And Alpha Globin 2) (Eg Alpha Thalassemia Hb Bart Hydrops Fetalis Syn- Drome Hbh Disease) Gene Analysis Common Deletions Or Variant (Eg Southeast Asian Thai Filipino Mediterranean Alpha3.7 Alpha4.2 Alpha20.5 And Constant Spring) (Desc Revised 1/1/2018)
81258-CPTModerateHba1/Hba2 (Alpha Globin 1 And Alpha Globin 2) (Eg Alpha Thalassemia Hb Bart Hydrops Fetalis Syndrome Hbh Disease) Gene Analysis; Known Familial Variant

What is a fee schedule?

A fee schedule is a list of fixed prices that healthcare providers charge for specific services, including CPT 81257. These prices vary depending on payer type (Medicare, Medicaid, private insurance), geographic location, and provider contracts.

Understanding the 81257 fee schedule helps patients estimate costs and providers optimize billing for accurate reimbursements.

Factors that affect fee schedules


Medicare & Medicaid Rates

Government-set reimbursement amounts


Private Insurance Rates

Negotiated rates between providers and insurance companies


Geographic Location

Costs may be higher in urban areas.


Provider Type

Hospital providers may have different rates than private practice.

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