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See a sample rate comparisonHealthcare providers use this code to document and receive reimbursement for visits that address moderate-level medical decision-making, often including multiple diagnoses or prescription management.
| Key Fact | Detail |
|---|---|
| Service Type | Pathology and Laboratory Procedures Molecular Pathology Procedures |
| Common Place of Service | 81 - Independent Laboratory 21 - Inpatient Hospital 22 - On Campus Outpatient Hospital |
| Common Modifiers | None 59 - Distinct Procedural Service |
| Complexity Level | Low |
| Medicare Fee Schedule | View Medicare rates for 81348 |
| Medicaid Fee Schedule | View Medicaid rates for 81348 |
National average reimbursement for CPT 81348 by major payers:

$159.31

$107.51

$161.42

$265.95
Choose a payer to see a sample of rates for CPT 81348.
Merrimack Valley Pediatric Associates, Inc.
Samaritan Emergency Medical Services PC
Merrimack Valley Pediatric Associates, Inc.
Good Samaritan Hosptial Medical Center
Florida Gulf Coast Ear, Nose And Throat, LLC
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Rate Benchmarking
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See a sample rate comparisonPayer Contract Negotiation
Use your fee schedule and market benchmarks to set target rates and draft a letter for your payer.
See a sample payer proposalCPT 81348 vs. Other Molecular Pathology Procedures Codes
The CPT 81348 code is part of the Pathology and Laboratory Procedures services used for Molecular Pathology Procedures. It represents a moderate-complexity encounter and is one of several codes that vary based on time spent, level of medical decision-making, and documentation requirements.
The CPT 81348 code involves more provider time and moderate medical decision-making, unlike lower-level codes that require less time and simpler assessments. It typically includes multiple diagnoses, medication management, or test interpretation, leading to higher reimbursement and more detailed documentation requirements.
| Code | Complexity | Description |
|---|---|---|
| 81347-CPT | Low | Sf3b1 Gene Common Variants, Sf3b1 Splicing Factor 3b Subunit B1 Eg Myelodysplastic Syndrome Acute Myeloid Leukemia Gene Analysis Common Variants Eg A672t E622d L833f R625c R625l |
| 81348-CPT | Low | Srsf2 Gene Common Variants, Srsf2 Serine And Arginine Rich Splicing Factor 2 Eg Myelodysplastic Syndrome Acute Myeloid Leukemia Gene Analysis Common Variants Eg P95h P95l |
| 81349-CPT | High | Cytogenomic (Genome-Wide) Anal, Cytogenomic (Genome-Wide) Analysis For Constitutional Chromosomal Abnormalities Interrogation Of Genomic Regions For Copy Number And Loss-Of-Heterozygosity Variants Low-Pass Sequencing Analysis |
What is a fee schedule?
A fee schedule is a list of fixed prices that healthcare providers charge for specific services, including CPT 81348. These prices vary depending on payer type (Medicare, Medicaid, private insurance), geographic location, and provider contracts.
Understanding the 81348 fee schedule helps patients estimate costs and providers optimize billing for accurate reimbursements.
Factors that affect fee schedules
Medicare & Medicaid Rates
Government-set reimbursement amounts
Private Insurance Rates
Negotiated rates between providers and insurance companies
Geographic Location
Costs may be higher in urban areas.
Provider Type
Hospital providers may have different rates than private practice.
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