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CPT 81349 Fee Schedule

Last Verified: September 2026

Healthcare providers use this code to document and receive reimbursement for visits that address high-level medical decision-making, often including multiple diagnoses or prescription management.

Key FactDetail
Service Type

Pathology and Laboratory Procedures

Molecular Pathology Procedures

Common Place of Service

81 - Independent Laboratory

11 - Office

Common Modifiers

None

59 - Distinct Procedural Service

Complexity LevelHigh
Medicare Fee ScheduleView Medicare rates for 81349
Medicaid Fee ScheduleView Medicaid rates for 81349

National average reimbursement for CPT 81349 by major payers:

bcbs

$1,037.39

uhc

$709.37

aetna

$1,057.52

cigna

$1,695.62

CPT 81349 vs. Other Molecular Pathology Procedures Codes

The CPT 81349 code is part of the Pathology and Laboratory Procedures services used for Molecular Pathology Procedures. It represents a moderate-complexity encounter and is one of several codes that vary based on time spent, level of medical decision-making, and documentation requirements.

The CPT 81349 code involves more provider time and moderate medical decision-making, unlike lower-level codes that require less time and simpler assessments. It typically includes multiple diagnoses, medication management, or test interpretation, leading to higher reimbursement and more detailed documentation requirements.

CodeComplexityDescription
81348-CPTLow
Srsf2 Gene Common Variants, Srsf2 Serine And Arginine Rich Splicing Factor 2 Eg Myelodysplastic Syndrome Acute Myeloid Leukemia Gene Analysis Common Variants Eg P95h P95l
81349-CPTHigh
Cytogenomic (Genome-Wide) Anal, Cytogenomic (Genome-Wide) Analysis For Constitutional Chromosomal Abnormalities Interrogation Of Genomic Regions For Copy Number And Loss-Of-Heterozygosity Variants Low-Pass Sequencing Analysis
81350-CPTLow
Ugt1a1 Gene Common Variants, Ugt1a1 Udp Glucuronosyltransferase 1 Family Polypeptide A1 Eg Drug Metabolism Hereditary Unconjugated Hyperbilirubinemia Gilbert Syndrome Gene Analysis Common Variants Eg 28 36 37

What is a fee schedule?

A fee schedule is a list of fixed prices that healthcare providers charge for specific services, including CPT 81349. These prices vary depending on payer type (Medicare, Medicaid, private insurance), geographic location, and provider contracts.

Understanding the 81349 fee schedule helps patients estimate costs and providers optimize billing for accurate reimbursements.

Factors that affect fee schedules


Medicare & Medicaid Rates

Government-set reimbursement amounts


Private Insurance Rates

Negotiated rates between providers and insurance companies


Geographic Location

Costs may be higher in urban areas.


Provider Type

Hospital providers may have different rates than private practice.

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