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See a sample rate comparisonHealthcare providers use this code to document and receive reimbursement for visits that address moderate-level medical decision-making, often including multiple diagnoses or prescription management.
| Key Fact | Detail |
|---|---|
| Service Type | Pathology and Laboratory Procedures Genomic Sequencing Procedures and Other Molecular Multianalyte Assays |
| Common Place of Service | 81 - Independent Laboratory 11 - Office |
| Common Modifiers | None 90 - Reference Laboratory 59 - Distinct Procedural Service |
| Complexity Level | Moderate |
| Medicare Fee Schedule | View Medicare rates for 81420 |
| Medicaid Fee Schedule | View Medicaid rates for 81420 |
National average reimbursement for CPT 81420 by major payers:

$608.92

$476.69

$723.12

$1,068.02
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See a sample payer proposalCPT 81420 vs. Other Genomic Sequencing Procedures and Other Molecular Multianalyte Assays Codes
The CPT 81420 code is part of the Pathology and Laboratory Procedures services used for Genomic Sequencing Procedures and Other Molecular Multianalyte Assays. It represents a moderate-complexity encounter and is one of several codes that vary based on time spent, level of medical decision-making, and documentation requirements.
The CPT 81420 code involves more provider time and moderate medical decision-making, unlike lower-level codes that require less time and simpler assessments. It typically includes multiple diagnoses, medication management, or test interpretation, leading to higher reimbursement and more detailed documentation requirements.
| Code | Complexity | Description |
|---|---|---|
| 81407-CPT | Moderate | Mopath Procedure Level 8, Molecular Pathology Procedure Level 8 (Eg Analysis Of 26-50 Exons By Dna Sequence Analysis Mutation Scanning Or Duplication Deletion Variants Of >50 Exons Sequence Analysis Of Multiple Genes On One Platform) Abcc8 (Atp-Binding Cassette Sub-Family C [Cftr Mrp] Member 8) (Eg Familial Hyperinsulinism) Full Gene Sequence Agl (Amylo-Alpha-1 6-Glucosidase 4-Alpha-Glucanotransferase) (Eg Glycogen Storage Disease Type Iii) Full Gene Sequence Ahi1 (Abelson Helper Integration Site 1) (Eg Joubert Syndrome) Full Gene Sequence Apob (Apolipoprotein B) (Eg Familial Hypercholesterolemia Type B) Full Gene Sequence Aspm (Asp [Abnormal Spindle] Homolog Microcephaly Associated [Drosophila]) (Eg Primary Microcephaly) Full Gene Sequence Chd7 (Chromodomain Helicase Dna Binding Protein 7) (Eg Charge Syndrome) Full Gene Sequence Col4a4 (Collagen Type Iv Alpha 4) (Eg Alport Syndrome) Full Gene Sequence Col4a5 (Collagen Type Iv Alpha 5) (Eg Alport Syndrome) Duplication Deletion Analysis Col6a1 (Collagen Type Vi Alpha 1) (Eg Collagen Type Vi-Related Disorders) Full Gene Sequence Col6a2 (Collagen Type Vi Alpha 2) (Eg Collagen Type Vi-Related Disorders) Full Gene Sequence Col6a3 (Collagen Type Vi Alpha 3) (Eg Collagen Type Vi-Related Disorders) Full Gene Sequence Crebbp (Creb Binding Protein) (Eg Rubinstein-Taybi Syndrome) Full Gene Sequence F8 (Coagulation Factor Viii) (Eg Hemophilia A) Full Gene Sequence Jag1 (Jagged 1) (Eg Alagille Syndrome) Full Gene Sequence Kdm5c (Lysine Demethylase 5c) (Eg X-Linked Intellectual Disability) Full Gene Sequence Kiaa0196 (Kiaa0196) (Eg Spastic Paraplegia) Full Gene Sequence L1cam (L1 Cell Adhesion Molecule) (Eg Masa Syndrome X-Linked Hydrocephaly) Full Gene Sequence Lamb2 (Laminin Beta 2 [Laminin S]) (Eg Pierson Syndrome) Full Gene Sequence Mybpc3 (Myosin Binding Protein C Cardiac) (Eg Familial Hypertrophic Cardiomyopathy) Full Gene Sequence Myh6 (Myosin Heavy Chain 6 Cardiac Muscle Alpha) (Eg Familial Dilated Cardiomyopathy) Full Gene Sequence Myh7 (Myosin Heavy Chain 7 Cardiac Muscle Beta) (Eg Familial Hypertrophic Cardiomyopathy Liang Distal Myopathy) Full Gene Sequence Myo7a (Myosin Viia) (Eg Usher Syndrome Type 1) Full Gene Sequence Notch1 (Notch 1) (Eg Aortic Valve Disease) Full Gene Sequence Nphs1 (Nephrosis 1 Congenital Finnish Type [Nephrin]) (Eg Congenital Finnish Nephrosis) Full Gene Sequence Opa1 (Optic Atrophy 1) (Eg Optic Atrophy) Full Gene Sequence Pcdh15 (Protocadherin-Related 15) (Eg Usher Syndrome Type 1) Full Gene Sequence Pkd1 (Polycystic Kidney Disease 1 [Autosomal Dominant]) (Eg Polycystic Kidney Disease) Full Gene Sequence Plce1 (Phospholipase C Epsilon 1) (Eg Nephrotic Syndrome Type 3) Full Gene Sequence Scn1a (Sodium Channel Voltage-Gated Type 1 Alpha Subunit) (Eg Generalized Epilepsy With Febrile Seizures) Full Gene Sequence Scn5a (Sodium Channel Voltage-Gated Type V Alpha Subunit) (Eg Familial Dilated Cardiomyopathy) Full Gene Sequence Slc12a1 (Solute Carrier Family 12 [Sodium Potassium Chloride Transporters] Member 1) (Eg Bartter Syndrome) Full Gene Sequence Slc12a3 (Solute Carrier Family 12 [Sodium Chloride Transporters] Member 3) (Eg Gitelman Syndrome) Full Gene Sequence Spg11 (Spastic Paraplegia 11 [Autosomal Recessive]) (Eg Spastic Paraplegia) Full Gene Sequence Sptbn2 (Spectrin Beta Non-Erythrocytic 2) (Eg Spinocerebellar Ataxia) Full Gene Sequence Tmem67 (Transmembrane Protein 67) (Eg Joubert Syndrome) Full Gene Sequence Tsc2 (Tuberous Sclerosis 2) (Eg Tuberous Sclerosis) Full Gene Sequence Ush1c (Usher Syndrome 1c [Autosomal Recessive Severe]) (Eg Usher Syndrome Type 1) Full Gene Sequence Vps13b (Vacuolar Protein Sorting 13 Homolog B [Yeast]) (Eg Cohen Syndrome) Duplication Deletion Analysis Wdr62 (Wd Repeat Domain 62) (Eg Primary Autosomal Recessive Microcephaly) Full Gene Sequence |
| 81420-CPT | Moderate | Fetal Chromosomal Aneuploidy (, Fetal Chromosomal Aneuploidy (Eg Trisomy 21 Monosomy X) Genomic Sequence Analysis Panel Circulating Cell-Free Fetal Dna In Maternal Blood Must Include Analysis Of Chromosomes 13 18 And 21 |
| 81422-CPT | Moderate | Fetal Chromosomal Microdeletio, Fetal Chromosomal Microdeletion(S) Genomic Sequence Analysis (Eg Digeorge Syndrome Cri-Du-Chat Syndrome) Circulating Cell-Free Fetal Dna In Maternal Blood |
| 81442-CPT | High | Noonan Spectrum Disorders, Noonan Spectrum Disorders Eg Noonan Syndrome Cardio Facio Cutaneous Syndrome Costello Syndrome Leopard Syndrome Noonan Like Syndrome Genomic Sequence Analysis Panel Must Include Sequencing Of At Least 12 Genes Including Braf Cbl Hras Kras Map2k1 Map2k2 Nras Ptpn11 Raf1 Rit1 Shoc2 And Sos1 |
What is a fee schedule?
A fee schedule is a list of fixed prices that healthcare providers charge for specific services, including CPT 81420. These prices vary depending on payer type (Medicare, Medicaid, private insurance), geographic location, and provider contracts.
Understanding the 81420 fee schedule helps patients estimate costs and providers optimize billing for accurate reimbursements.
Factors that affect fee schedules
Medicare & Medicaid Rates
Government-set reimbursement amounts
Private Insurance Rates
Negotiated rates between providers and insurance companies
Geographic Location
Costs may be higher in urban areas.
Provider Type
Hospital providers may have different rates than private practice.
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