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CPT 81455 Fee Schedule

Last Verified: January 2026

Healthcare providers use this code to document and receive reimbursement for visits that address high-level medical decision-making, often including multiple diagnoses or prescription management.

Targeted Genomic Sequence Analysis Panel Solid Organ Or Hematolymphoid Neoplasm Or Disorder 51 Or Greater Genes (Eg Alk Braf Cdkn2a Cebpa Dnmt3a Egfr Erbb2 Ezh2 Flt3 Idh1 Idh2 Jak2 Kit Kras Met Mll Notch1 Npm1 Nras Pdgfra Pdgfrb Pgr Pik3ca Pten Ret) Tch1 Pdgfra Pdgfrbpgr Pik3ca Pten Ret) Interrogation For Sequence Variants And Copy Number Variants Or Rearrangements Or Isoform Expression Or Mrna Expression Levels If Performed; Dna Analysis Or(Desc Rvsd 1/1/23)
Key FactDetail
Service Type

Pathology and Laboratory Procedures

Genomic Sequencing Procedures and Other Molecular Multianalyte Assays

Common Place of Service

81 - Independent Laboratory

22 - On Campus Outpatient Hospital

Common Modifiers

None

90 - Reference Laboratory

26 - Professional component

Complexity LevelHigh
Medicare Fee ScheduleView Medicare rates for 81455

National average reimbursement for CPT 81455 by major payers:

bcbs

$2,154.97

uhc

$1,788.49

aetna

$2,654.06

cigna

$4,226.45

Preview provider-level rates for...
For billing codeCPT 81455
PayerCodeRateNPITax IDStateSpecialty

Select a payer to view fee schedule data

Choose a payer from the options above to see rates for CPT 81455

United
81455$1226.221619270683 - CATALINA SKIN INSTITUTE, LLC204706226AZClinical Medical Laboratory (291U00000X)
United
81455$1459.801235400839 - COMPUNET CLINICAL LABORATORIES, LLC311258010OHClinical Medical Laboratory (291U00000X)
United
81455$2919.601861822991 - THEDACARE REGIONAL MEDICAL CENTER, APPLETON MEDICAL CENTER, INC.390830664WIClinical Medical Laboratory (291U00000X)
United
81455$3608.251457516650 - DYNACARE NORTHWEST INC., HAWTHORNE HILLS840611484WAClinical Medical Laboratory (291U00000X)
United
81455$1459.801679820534 - NEW VISION MEDICAL LABORATORIES, LLC341913433OHClinical Medical Laboratory (291U00000X)
United
81455$1751.761043330202 - ALABAMA PATHOLOGY ASSOCIATES631008587ALClinical Medical Laboratory (291U00000X)
United
81455$3864.531376853804 - LABORATORY CORPORATION OF AMERICA HOLDINGS133757370VAClinical Medical Laboratory (291U00000X)
United
81455$2780.361124805064 - LABORATORY CORPORATION OF AMERICA840611484ILClinical Medical Laboratory (291U00000X)
United
81455$2746.031285014282 - LABORATORY CORPORATION OF AMERICA HOLDINGS133757370KSClinical Medical Laboratory (291U00000X)
United
81455$1877.301205923612 - SONORA QUEST LABORATORIES LLC, SONORA QUEST LABORATORIES OF TUCSON860872873AZClinical Medical Laboratory (291U00000X)
United
81455$2780.361407638430 - LABORATORY CORPORATION OF AMERICA840611484COClinical Medical Laboratory (291U00000X)
United
81455$2746.031720631153 - LABORATORY CORPORATION OF AMERICA840611484ILClinical Medical Laboratory (291U00000X)
United
81455$3608.251205210036 - LABORATORY CORPORATION OF AMERICA840611484AZClinical Medical Laboratory (291U00000X)
United
81455$1576.571285810903 - BALTIMORE WASHINGTON MEDICAL CENTER521655640MDClinical Medical Laboratory (291U00000X)
United
81455$2746.031073599478 - LABORATORY CORPORATION OF AMERICA133757370WAClinical Medical Laboratory (291U00000X)
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist

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CPT 81455 vs. Other Genomic Sequencing Procedures and Other Molecular Multianalyte Assays Codes

The CPT 81455 code is part of the Pathology and Laboratory Procedures services used for Genomic Sequencing Procedures and Other Molecular Multianalyte Assays. It represents a moderate-complexity encounter and is one of several codes that vary based on time spent, level of medical decision-making, and documentation requirements.

The CPT 81455 code involves more provider time and moderate medical decision-making, unlike lower-level codes that require less time and simpler assessments. It typically includes multiple diagnoses, medication management, or test interpretation, leading to higher reimbursement and more detailed documentation requirements.

CodeComplexityDescription
81445-CPTModerateTargeted Genomic Sequence Analysis Panel Solid Organ Neoplasm 5-50 Genes (Eg Alk Braf Cdkn2a Egfr Erbb2 Kit Kras Met Nras Pdgfra Pdgfrb Pgr Pik3ca Pten Ret) Interrogation For Sequence Variants And Copy Number Variants Or Rearrangements If Performed; Dna Analysis Or Combined Dna And Rna Analysis (Desc Rvsd 1/1/23)
81449-CPTModerateTargeted Genomic Sequence Analysis Panel, Solid Organ Neoplasm, 5-50 Genes (Eg, Alk, Braf, Cdkn2a, Egfr, Erbb2, Kit, Kras, Met, Nras, Pdgfra, Pdgfrb, Pgr, Pik3ca, Pten, Ret), Interrogation For Sequence Variants And Copy Number Variants Or Rearrangements, If Performed; Rna Analysis
81450-CPTModerateTargeted Genomic Sequence Analysis Panel Hematolymphoid Neoplasm Or Disorder 5-50 Genes (Eg Braf Cebpa Dnmt3a Ezh2 Flt3 Idh1 Idh2 Jak2 Kit Kras Mll Notch1 Npm1 Nras) Interrogation For Sequence Variants And Copy Number Variants Or Rearrangements Or Isoform Expression Or Mrna Expression Levels If Performed; Dna Analysis Or Combined Dna And Rna Analysis (Desc Rvsd 1/1/23)
81455-CPTHighTargeted Genomic Sequence Analysis Panel Solid Organ Or Hematolymphoid Neoplasm Or Disorder 51 Or Greater Genes (Eg Alk Braf Cdkn2a Cebpa Dnmt3a Egfr Erbb2 Ezh2 Flt3 Idh1 Idh2 Jak2 Kit Kras Met Mll Notch1 Npm1 Nras Pdgfra Pdgfrb Pgr Pik3ca Pten Ret) Tch1 Pdgfra Pdgfrbpgr Pik3ca Pten Ret) Interrogation For Sequence Variants And Copy Number Variants Or Rearrangements Or Isoform Expression Or Mrna Expression Levels If Performed; Dna Analysis Or(Desc Rvsd 1/1/23)

What is a fee schedule?

A fee schedule is a list of fixed prices that healthcare providers charge for specific services, including CPT 81455. These prices vary depending on payer type (Medicare, Medicaid, private insurance), geographic location, and provider contracts.

Understanding the 81455 fee schedule helps patients estimate costs and providers optimize billing for accurate reimbursements.

Factors that affect fee schedules


Medicare & Medicaid Rates

Government-set reimbursement amounts


Private Insurance Rates

Negotiated rates between providers and insurance companies


Geographic Location

Costs may be higher in urban areas.


Provider Type

Hospital providers may have different rates than private practice.

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