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CPT 81508 Fee Schedule

Last Verified: September 2026

Healthcare providers use this code to document and receive reimbursement for visits that address moderate-level medical decision-making, often including multiple diagnoses or prescription management.

Key FactDetail
Service Type

Pathology and Laboratory Procedures

Multianalyte Assays with Algorithmic Analyses

Common Place of Service

81 - Independent Laboratory

11 - Office

Common Modifiers

None

90 - Reference Laboratory

XU - Unusual Non-Overlapping Service

Complexity LevelLow
Medicare Fee ScheduleView Medicare rates for 81508
Medicaid Fee ScheduleView Medicaid rates for 81508

National average reimbursement for CPT 81508 by major payers:

bcbs

$44.64

uhc

$33.27

aetna

$77.59

cigna

$97.90

CPT 81508 vs. Other Multianalyte Assays with Algorithmic Analyses Codes

The CPT 81508 code is part of the Pathology and Laboratory Procedures services used for Multianalyte Assays with Algorithmic Analyses. It represents a moderate-complexity encounter and is one of several codes that vary based on time spent, level of medical decision-making, and documentation requirements.

The CPT 81508 code involves more provider time and moderate medical decision-making, unlike lower-level codes that require less time and simpler assessments. It typically includes multiple diagnoses, medication management, or test interpretation, leading to higher reimbursement and more detailed documentation requirements.

CodeComplexityDescription
81490-CPTModerate
Autoimmune (Rheumatoid Arthrit, Autoimmune (Rheumatoid Arthritis) Analysis Of 12 Biomarkers Using Immunoassays Utilizing Serum Prognostic Algorithm Reported As A Disease Activity Score
81493-CPTModerate
Coronary Artery Disease Mrna, Coronary Artery Disease Mrna Gene Expression Profiling By Real-Time Rt-Pcr Of 23 Genes Utilizing Whole Peripheral Blood Algorithm Reported As A Risk Score
81506-CPTLow
Endo Assay Seven Anal, Endocrinology Type 2 Diabetes Biochemical Assays Of Seven Analytes Glucose Hba1c Insulin Hs Crp Adiponectin Ferritin Interleukin 2 Receptor Alpha Utilizing Serum Or Plasma Algorithm Reporting A Risk Score
81508-CPTLow
Ftl Cgen Abnor Two Proteins, Fetal Congenital Abnormalities Biochemical Assays Of Two Proteins Papp A Hcg Any Form Utilizing Maternal Serum Algorithm Reported As A Risk Score

What is a fee schedule?

A fee schedule is a list of fixed prices that healthcare providers charge for specific services, including CPT 81508. These prices vary depending on payer type (Medicare, Medicaid, private insurance), geographic location, and provider contracts.

Understanding the 81508 fee schedule helps patients estimate costs and providers optimize billing for accurate reimbursements.

Factors that affect fee schedules


Medicare & Medicaid Rates

Government-set reimbursement amounts


Private Insurance Rates

Negotiated rates between providers and insurance companies


Geographic Location

Costs may be higher in urban areas.


Provider Type

Hospital providers may have different rates than private practice.

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