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See a sample rate comparisonCPT 81541 Fee Schedule
Last Verified: October 2026
Healthcare providers use this code to document and receive reimbursement for visits that address high-level medical decision-making, often including multiple diagnoses or prescription management.
Oncology (Prostate) Mrna Gene, Oncology (Prostate) Mrna Gene Expression Profiling By Real-Time Rt-Pcr Of 46 Genes (31 Content And 15 Housekeeping) Utilizing Formalin-Fixed Paraffin-Embedded Tissue Algorithm Reported As A Disease-Specific Mortality Risk Score Hpa-9ab (V837m)
| Key Fact | Detail |
|---|---|
| Service Type | Pathology and Laboratory Procedures Multianalyte Assays with Algorithmic Analyses |
| Common Place of Service | 81 - Independent Laboratory 11 - Office |
| Complexity Level | High |
| Medicare Fee Schedule | $3,873.00 national lab fee schedule rate (2026) · View Medicare rates for 81541 |
| Medicaid Fee Schedule | $3,834.27 median of the 8 states in the free preview · View Medicaid rates for 81541 |
National average reimbursement for CPT 81541 by major payers:
$2,875.64
$2,364.04
$3,533.27
$5,318.96
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CPT 81541
5 of 25 sample ratesHigher to lower in this preview
Chu Chen
Merrimack Valley Pediatric Associates, Inc.
$8,520.60Published rateChristopher Raio
Mercy Medical Center
$4,601.12Published rateBaycare Home Care, Inc.
Baycare Home Care Inc
$2,856.11Published rateChristopher Raio
Samaritan Emergency Medical Services PC
$2,323.80Published rateE And A Medical On The Go Healthcare Of South Florida LLC, E And A Healthcare On The Go
E And A Medical On The Go Healthcare Of South Florida LLC
$1,355.55Published rate
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See a sample payer proposalCPT 81541 vs. Other Multianalyte Assays with Algorithmic Analyses Codes
The CPT 81541 code is part of the Pathology and Laboratory Procedures services used for Multianalyte Assays with Algorithmic Analyses. It represents a moderate-complexity encounter and is one of several codes that vary based on time spent, level of medical decision-making, and documentation requirements.
The CPT 81541 code involves more provider time and moderate medical decision-making, unlike lower-level codes that require less time and simpler assessments. It typically includes multiple diagnoses, medication management, or test interpretation, leading to higher reimbursement and more detailed documentation requirements.
| Code | Complexity | Description |
|---|---|---|
| 81539-CPT | Moderate | Oncology Prostate Prob Score, Oncology High Grade Prostate Cancer Biochemical Assay Of Four Proteins Total Psa Free Psa Intact Psa And Human Kallikrein 2 Hk2 Utilizing Plasma Or Serum Prognostic Algorithm Reported As A Probability Score |
| 81541-CPT | High | Oncology (Prostate) Mrna Gene, Oncology (Prostate) Mrna Gene Expression Profiling By Real-Time Rt-Pcr Of 46 Genes (31 Content And 15 Housekeeping) Utilizing Formalin-Fixed Paraffin-Embedded Tissue Algorithm Reported As A Disease-Specific Mortality Risk Score Hpa-9ab (V837m) |
| 81542-CPT | High | Onc Prostate Mrna 22 Cnt Gen, Oncology Prostate Mrna Microarray Gene Expression Profiling Of 22 Content Genes Utilizing Formalin Fixed Paraffin Embedded Tissue Algorithm Reported As Metastasis Risk Score |
| 81546-CPT | High | Onc Thyr Mrna 10 196 Gen Alg, Oncology Thyroid Mrna Gene Expression Analysis Of 10 196 Genes Utilizing Fine Needle Aspirate Algorithm Reported As A Categorical Result Eg Benign Or Suspicious |
What is a fee schedule?
A fee schedule is a list of fixed prices that healthcare providers charge for specific services, including CPT 81541. These prices vary depending on payer type (Medicare, Medicaid, private insurance), geographic location, and provider contracts.
Understanding the 81541 fee schedule helps patients estimate costs and providers optimize billing for accurate reimbursements.
Factors that affect fee schedules
Medicare & Medicaid Rates
Government-set reimbursement amounts
Private Insurance Rates
Negotiated rates between providers and insurance companies
Geographic Location
Costs may be higher in urban areas.
Provider Type
Hospital providers may have different rates than private practice.
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