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CPT 81546 Fee Schedule

Last Verified: December 2025

Healthcare providers use this code to document and receive reimbursement for visits that address high-level medical decision-making, often including multiple diagnoses or prescription management.

Oncology (Thyroid) Mrna Gene Expression Analysis Of 10 196 Genes Utilizing Fine Needle Aspirate Algorithm Reported As A Categorical Result (Eg Benign Or Suspicious)
Key FactDetail
Service Type

Pathology and Laboratory Procedures

Multianalyte Assays with Algorithmic Analyses

Common Place of Service

81 - Independent Laboratory

Common Modifiers

None

59 - Distinct Procedural Service

Complexity LevelHigh

National average reimbursement for CPT 81546 by major payers:

bcbs

$3,323.37

uhc

$2,196.65

aetna

$3,298.12

cigna

$5,143.87

Preview provider-level rates for...
For billing codeCPT 81546
PayerCodeRateNPITax IDStateSpecialty

Select a payer to view fee schedule data

Choose a payer from the options above to see rates for CPT 81546

United
81546$1260.001598375651 - E AND A MEDICAL ON THE GO HEALTHCARE OF SOUTH FLORIDA LLC, E AND A HEALTHCARE ON THE GO832289173 - (FL) E AND A MEDICAL ON THE GO HEALTHCARE OF SOUTH FLORIDA LLCFLHome Health Agency (251E00000X)
United
81546$2160.001255478004 - CHRISTOPHER RAIO208243412 - SAMARITAN EMERGENCY MEDICAL SERVICES PCNYEmergency Medicine Physician (207P00000X)
United
81546$4752.001255478004 - CHRISTOPHER RAIO111635088 - MERCY MEDICAL CENTERNYEmergency Medicine Physician (207P00000X)
United
81546$3609.501497207146 - MELANIE SMITH521958352 - ATLANTIC HEALTH SYSTEM INCNJRegistered Dietitian (133V00000X)
United
81546$4752.001255478004 - CHRISTOPHER RAIO208243412 - SAMARITAN EMERGENCY MEDICAL SERVICES PCNYEmergency Medicine Physician (207P00000X)
United
81546$3672.001184809220 - AHS HOSPITAL CORP521958352 - ATLANTIC HEALTH SYSTEM INCNJCase Management Agency (251B00000X)
United
81546$3600.001073502985 - CHU CHEN42484572 - MERRIMACK VALLEY PEDIATRIC ASSOCIATES, INC.MAPediatrics Physician (208000000X)
United
81546$2160.001861650780 - CHILDRENS NATIONAL MEDICAL CENTER530196580 - CHILDRENS HOSPITALDCChildren's Hospital (282NC2000X)
United
81546$1944.001255478004 - CHRISTOPHER RAIO111635088 - MERCY MEDICAL CENTERNYEmergency Medicine Physician (207P00000X)
United
81546$7920.001073502985 - CHU CHEN42484572 - MERRIMACK VALLEY PEDIATRIC ASSOCIATES, INC.MAPediatrics Physician (208000000X)
United
81546$3596.401255478004 - CHRISTOPHER RAIO111635088 - MERCY MEDICAL CENTERNYEmergency Medicine Physician (207P00000X)
United
81546$1512.001003166612 - MATTHEW LILLEY931261079 - THE ORTHOPEDIC AND NEUROSURGICAL CENTER OF THE CASCADESOROrthopaedic Surgery Physician (207X00000X)
United
81546$4752.001255478004 - CHRISTOPHER RAIO208243412 - SAMARITAN EMERGENCY MEDICAL SERVICES PCNYEmergency Medicine Physician (207P00000X)
United
81546$5400.001003166612 - MATTHEW LILLEY680637976 - BEND MEMORIAL CLINIC, PCOROrthopaedic Surgery Physician (207X00000X)
United
81546$1512.001447317110 - BAPTIST HEALTH CARE, INC., BAPTIST HOME HEALT CARE AND MEDICAL EQUIPMENT590657322 - BAPTIST HEALTH CARE INCFLHome Health Agency (251E00000X)
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist
United
99202$100.0012345678901234567890CACardiologist

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CPT 81546 vs. Other Multianalyte Assays with Algorithmic Analyses Codes

The CPT 81546 code is part of the Pathology and Laboratory Procedures services used for Multianalyte Assays with Algorithmic Analyses. It represents a moderate-complexity encounter and is one of several codes that vary based on time spent, level of medical decision-making, and documentation requirements.

The CPT 81546 code involves more provider time and moderate medical decision-making, unlike lower-level codes that require less time and simpler assessments. It typically includes multiple diagnoses, medication management, or test interpretation, leading to higher reimbursement and more detailed documentation requirements.

CodeComplexityDescription
81541-CPTHighOncology (Prostate) Mrna Gene Expression Profiling By Real-Time Rt-Pcr Of 46 Genes (31 Content And 15 Housekeeping) Utilizing Formalin- Fixed Paraffin Embedded Tissue Algorithm Reported As A Disease-Specific Mortality Risk Scor
81542-CPTHighOncology (Prostate) Mrna Microarray Gene Expression Profiling Of 22 Content Genes Utilizinformalin-Fixed Paraffin-Embedded Tissue Algorithm Reported As Metastasis Risk Score
81546-CPTHighOncology (Thyroid) Mrna Gene Expression Analysis Of 10 196 Genes Utilizing Fine Needle Aspirate Algorithm Reported As A Categorical Result (Eg Benign Or Suspicious)
81551-CPTHighOncology (Prostate) Promoter Methylation Profiling By Real-Time Pcr Of 3 Genes (Gstp1 Apc Rassf1) Utilizing Formalin-Fixed Paraffin Embedded Tissue Algorithm Reported As A Likelihood Of Prostate Cancer Detection On Repeat Biopsy

What is a fee schedule?

A fee schedule is a list of fixed prices that healthcare providers charge for specific services, including CPT 81546. These prices vary depending on payer type (Medicare, Medicaid, private insurance), geographic location, and provider contracts.

Understanding the 81546 fee schedule helps patients estimate costs and providers optimize billing for accurate reimbursements.

Factors that affect fee schedules


Medicare & Medicaid Rates

Government-set reimbursement amounts


Private Insurance Rates

Negotiated rates between providers and insurance companies


Geographic Location

Costs may be higher in urban areas.


Provider Type

Hospital providers may have different rates than private practice.

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