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CPT 80359 Fee Schedule

Last Verified: September 2026

Healthcare providers use this code to document and receive reimbursement for visits that address moderate-level medical decision-making, often including multiple diagnoses or prescription management.

Key FactDetail
Service Type

Pathology and Laboratory Procedures

Therapeutic Drug Assays

Common Place of Service

81 - Independent Laboratory

11 - Office

Common Modifiers

None

90 - Reference Laboratory

26 - Professional component

Complexity LevelLow
Medicare Fee ScheduleView Medicare rates for 80359
Medicaid Fee ScheduleView Medicaid rates for 80359

National average reimbursement for CPT 80359 by major payers:

bcbs

$19.41

uhc

$14.33

aetna

$2.38

cigna

$50.02

CPT 80359 vs. Other Therapeutic Drug Assays Codes

The CPT 80359 code is part of the Pathology and Laboratory Procedures services used for Therapeutic Drug Assays. It represents a moderate-complexity encounter and is one of several codes that vary based on time spent, level of medical decision-making, and documentation requirements.

The CPT 80359 code involves more provider time and moderate medical decision-making, unlike lower-level codes that require less time and simpler assessments. It typically includes multiple diagnoses, medication management, or test interpretation, leading to higher reimbursement and more detailed documentation requirements.

CodeComplexityDescription
80346-CPTLow
Sedative Therapy Monitoring, Benzodiazepines Are A Class Of Sedatives That Can Have Strong Effects. A Blood Analysis Helps To Determine A Therapeutic Dose And Can Show Other Issues Such As Overdosing.
80359-CPTLow
Drug Screening, This Test Measures The Amount Of Methylenedioxyamphetamines Present In Blood And Urine Samples.
80361-CPTLow
Opiate Drug Screening, This Test Measures The Amount Of Opiates (Narcotic Painkillers Such As Morphine Or Codeine) Present In Blood And Urine Samples.
80362-CPTLow
Opiate Drug Screening, This Test Measures The Amount Of Opiates (Narcotic Painkillers Such As Morphine Or Codeine) Present In Blood And Urine Samples.

What is a fee schedule?

A fee schedule is a list of fixed prices that healthcare providers charge for specific services, including CPT 80359. These prices vary depending on payer type (Medicare, Medicaid, private insurance), geographic location, and provider contracts.

Understanding the 80359 fee schedule helps patients estimate costs and providers optimize billing for accurate reimbursements.

Factors that affect fee schedules


Medicare & Medicaid Rates

Government-set reimbursement amounts


Private Insurance Rates

Negotiated rates between providers and insurance companies


Geographic Location

Costs may be higher in urban areas.


Provider Type

Hospital providers may have different rates than private practice.

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