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See a sample rate comparisonCPT 81540 Fee Schedule
Last Verified: October 2026
Healthcare providers use this code to document and receive reimbursement for visits that address high-level medical decision-making, often including multiple diagnoses or prescription management.
Oncology Tum Unknown Origin, Oncology Tumor Of Unknown Origin Mrna Gene Expression Profiling By Real Time Rt Pcr Of 92 Genes 87 Content And 5 Housekeeping To Classify Tumor Into Main Cancer Type And Subtype Utilizing Formalin Fixed Paraffin Embedded Tissue Algorithm Reported As A Probability Of A Predicted Main Cancer Type And Subtype
| Key Fact | Detail |
|---|---|
| Service Type | Pathology and Laboratory Procedures Multianalyte Assays with Algorithmic Analyses |
| Common Place of Service | 81 - Independent Laboratory |
| Common Modifiers | 59 - Distinct Procedural Service TC - Technical component |
| Complexity Level | High |
| Medicare Fee Schedule | $3,750.00 national lab fee schedule rate (2026) · View Medicare rates for 81540 |
| Medicaid Fee Schedule | $3,562.50 median of the 8 states in the free preview · View Medicaid rates for 81540 |
National average reimbursement for CPT 81540 by major payers:
$2,683.53
$2,073.79
$3,386.08
$5,420.56
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CPT 81540
5 of 25 sample ratesHigher to lower in this preview
Chu Chen
Merrimack Valley Pediatric Associates, Inc.
$8,250.00Published rateChu Chen
Merrimack Valley Pediatric Associates, Inc.
$3,750.00Published rateBaycare Home Care, Inc.
Baycare Home Care Inc
$2,153.55Published rateAusencio Nunez
Progressive Medical Center, S.C.
$1,606.17Published rateSunrise Home Health Care Inc.
Sunrise Home Health Care Inc
$1,168.11Published rate
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See a sample payer proposalCPT 81540 vs. Other Multianalyte Assays with Algorithmic Analyses Codes
The CPT 81540 code is part of the Pathology and Laboratory Procedures services used for Multianalyte Assays with Algorithmic Analyses. It represents a moderate-complexity encounter and is one of several codes that vary based on time spent, level of medical decision-making, and documentation requirements.
The CPT 81540 code involves more provider time and moderate medical decision-making, unlike lower-level codes that require less time and simpler assessments. It typically includes multiple diagnoses, medication management, or test interpretation, leading to higher reimbursement and more detailed documentation requirements.
| Code | Complexity | Description |
|---|---|---|
| 81540-CPT | High | Oncology Tum Unknown Origin, Oncology Tumor Of Unknown Origin Mrna Gene Expression Profiling By Real Time Rt Pcr Of 92 Genes 87 Content And 5 Housekeeping To Classify Tumor Into Main Cancer Type And Subtype Utilizing Formalin Fixed Paraffin Embedded Tissue Algorithm Reported As A Probability Of A Predicted Main Cancer Type And Subtype |
| 81541-CPT | High | Oncology (Prostate) Mrna Gene, Oncology (Prostate) Mrna Gene Expression Profiling By Real-Time Rt-Pcr Of 46 Genes (31 Content And 15 Housekeeping) Utilizing Formalin-Fixed Paraffin-Embedded Tissue Algorithm Reported As A Disease-Specific Mortality Risk Score Hpa-9ab (V837m) |
| 81542-CPT | High | Onc Prostate Mrna 22 Cnt Gen, Oncology Prostate Mrna Microarray Gene Expression Profiling Of 22 Content Genes Utilizing Formalin Fixed Paraffin Embedded Tissue Algorithm Reported As Metastasis Risk Score |
| 81546-CPT | High | Onc Thyr Mrna 10 196 Gen Alg, Oncology Thyroid Mrna Gene Expression Analysis Of 10 196 Genes Utilizing Fine Needle Aspirate Algorithm Reported As A Categorical Result Eg Benign Or Suspicious |
What is a fee schedule?
A fee schedule is a list of fixed prices that healthcare providers charge for specific services, including CPT 81540. These prices vary depending on payer type (Medicare, Medicaid, private insurance), geographic location, and provider contracts.
Understanding the 81540 fee schedule helps patients estimate costs and providers optimize billing for accurate reimbursements.
Factors that affect fee schedules
Medicare & Medicaid Rates
Government-set reimbursement amounts
Private Insurance Rates
Negotiated rates between providers and insurance companies
Geographic Location
Costs may be higher in urban areas.
Provider Type
Hospital providers may have different rates than private practice.
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