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See a sample rate comparisonHealthcare providers use this code to document and receive reimbursement for visits that address high-level medical decision-making, often including multiple diagnoses or prescription management.
| Key Fact | Detail |
|---|---|
| Service Type | Pathology and Laboratory Procedures Multianalyte Assays with Algorithmic Analyses |
| Common Place of Service | 81 - Independent Laboratory 11 - Office |
| Common Modifiers | 90 - Reference Laboratory GZ - Item or Service Expected to Be Denied as Not Reasonable and Necessary |
| Complexity Level | High |
| Medicare Fee Schedule | $2,030.00 national lab fee schedule rate (2026) · View Medicare rates for 81551 |
| Medicaid Fee Schedule | $2,030.00 median of the 8 states in the free preview · View Medicaid rates for 81551 |
National average reimbursement for CPT 81551 by major payers:

$1,514.21

$1,243.23

$1,869.98

$2,821.96
Choose a payer to see a sample of rates for CPT 81551.
Chu Chen
Merrimack Valley Pediatric Associates, Inc.
Christopher Raio
St Francis Hospital
Baycare Home Care, Inc.
Baycare Home Care Inc
Ausencio Nunez
Progressive Medical Center, S.C.
Sunrise Home Health Care Inc.
Sunrise Home Health Care Inc
Choose your state and specialty to build a report from payer-published rates.
Rate Benchmarking
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See a sample rate comparisonPayer Contract Negotiation
Use your fee schedule and market benchmarks to set target rates and draft a letter for your payer.
See a sample payer proposalCPT 81551 vs. Other Multianalyte Assays with Algorithmic Analyses Codes
The CPT 81551 code is part of the Pathology and Laboratory Procedures services used for Multianalyte Assays with Algorithmic Analyses. It represents a moderate-complexity encounter and is one of several codes that vary based on time spent, level of medical decision-making, and documentation requirements.
The CPT 81551 code involves more provider time and moderate medical decision-making, unlike lower-level codes that require less time and simpler assessments. It typically includes multiple diagnoses, medication management, or test interpretation, leading to higher reimbursement and more detailed documentation requirements.
| Code | Complexity | Description |
|---|---|---|
| 81541-CPT | High | Oncology (Prostate) Mrna Gene, Oncology (Prostate) Mrna Gene Expression Profiling By Real-Time Rt-Pcr Of 46 Genes (31 Content And 15 Housekeeping) Utilizing Formalin-Fixed Paraffin-Embedded Tissue Algorithm Reported As A Disease-Specific Mortality Risk Score Hpa-9ab (V837m) |
| 81542-CPT | High | Onc Prostate Mrna 22 Cnt Gen, Oncology Prostate Mrna Microarray Gene Expression Profiling Of 22 Content Genes Utilizing Formalin Fixed Paraffin Embedded Tissue Algorithm Reported As Metastasis Risk Score |
| 81546-CPT | High | Onc Thyr Mrna 10 196 Gen Alg, Oncology Thyroid Mrna Gene Expression Analysis Of 10 196 Genes Utilizing Fine Needle Aspirate Algorithm Reported As A Categorical Result Eg Benign Or Suspicious |
| 81551-CPT | High | Oncology (Prostate) Promoter, Oncology (Prostate) Promoter Methylation Profiling By Real-Time Pcr Of 3 Genes (Gstp1 Apc Rassf1) Utilizing Formalin-Fixed Paraffin-Embedded Tissue Algorithm Reported As A Likelihood Of Prostate Cancer Detection On Repeat Biopsy Hpa-9ab (V837m) |
What is a fee schedule?
A fee schedule is a list of fixed prices that healthcare providers charge for specific services, including CPT 81551. These prices vary depending on payer type (Medicare, Medicaid, private insurance), geographic location, and provider contracts.
Understanding the 81551 fee schedule helps patients estimate costs and providers optimize billing for accurate reimbursements.
Factors that affect fee schedules
Medicare & Medicaid Rates
Government-set reimbursement amounts
Private Insurance Rates
Negotiated rates between providers and insurance companies
Geographic Location
Costs may be higher in urban areas.
Provider Type
Hospital providers may have different rates than private practice.
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